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1.发明公开
公开(公告)号：EP3855453A1
公开(公告)日：2021-07-28
申请号：EP20153732.1
申请日：2020-01-24
摘要： The invention relates to a method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient's brain. This method comprises the steps of - providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from said epileptic zone to a propagation zone, and loading said models in a computerized platform personalized according to the patient's brain; - providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; - for said at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient's brain, epileptic seizures, and determining, for said hypothesis and epileptic seizures, a network of propagation zones; - for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient's brain, simulated electroencephalographic signals activity that is to be measured by the intracranial electrodes implanted according to said plurality of schemes; and - determining, from said plurality of intracranial implantation schemes, an optimized intracranial implantation scheme of the set of electroencephalographic electrodes.
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公开(公告)号：EP3346262A1
公开(公告)日：2018-07-11
申请号：EP17150839.3
申请日：2017-01-10
申请人： Universite d'Aix-Marseille (AMU) , INSERM (Institut National de la Santé et de la Recherche Médicale)
CPC分类号： G01N25/4866 , G01N33/48
摘要： The invention concerns a method and a system for diagnosing a pathology in a mammal in need thereof. The method according to the invention comprises the following steps: collecting a biological sample from said mammal, said biological sample comprising a protein mixture; obtaining an optical thermal denaturation profile of said biological sample; comparing said optical thermal denaturation profile of said biological sample with an optical thermal denaturation reference profile; and diagnosing the pathology.
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3.发明公开DISPOSITIF DISTRIBUTEUR DE FLUIDE A VOIES D'ENTREE/SORTIE FLUIDIQUE MULTIPLES RECONFIGURABLES 审中-公开DispOSITIF DISTRIBUTEUR DE FLUIDE A VOIES D'ENTREE / SORTIE FLUIDIQUE MULTIPLES RECONFIGURABLES
公开(公告)号：EP3158239A1
公开(公告)日：2017-04-26
申请号：EP15736549.5
申请日：2015-06-16
发明人： LAUNAY, Stéphane
IPC分类号： F16K11/076 , F16K11/085
CPC分类号： F16K11/076 , F16K11/0856
摘要： This fluid dispenser with multiple fluid inlet/outlet channels (114A, 116A) comprises a first cylindrical portion (106), having at least one lateral fluid inlet or outlet channel, comprising at least one fluid connection chamber (146) for fluidly connecting said lateral channel to at least one opening formed in a lower base (110) of said first cylindrical portion (106). It comprises a second cylindrical portion (112), having several lateral fluid inlet/outlet channels (114A, 116A) and with circular cylindrical boring, having an upper base (110) coinciding with the lower base of the first cylindrical portion (106). It comprises a rotary circular cylindrical core (138), disposed inside the second cylindrical portion (112) and having an upper base in contact with the lower base (110) of the first cylindrical portion (106), free in rotation inside the second cylindrical portion (112) and in which there is formed at least one conduit (140, 142) for fluidly connecting said opening to at least any one of the lateral channels (114A, 116A) of the second cylindrical portion (112).
摘要翻译： 具有多个流体入口/出口通道（114A，116A）的该流体分配器包括具有至少一个侧向流体入口或出口通道的第一圆柱形部分（106），其包括至少一个流体连接腔室（146），用于流体连接所述侧向 通道至形成在所述第一圆柱形部分（106）的下底座（110）中的至少一个开口。 它包括具有几个横向流体入口/出口通道（114A，116A）和圆柱形钻孔的第二圆柱形部分（112），其具有与第一圆柱形部分（106）的下基座重合的上基座（110）。 它包括设置在第二圆筒形部分（112）内部并具有与第一圆筒形部分（106）的下底座（110）接触的上底座的旋转圆筒形芯体（138），其在第二圆筒形部分 （112），并且其中形成有至少一个导管（140,142），用于将所述开口流体连接到所述第二圆柱形部分（112）的至少任何一个所述侧向通道（114A，116A）。
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公开(公告)号：EP3156046A1
公开(公告)日：2017-04-19
申请号：EP15306656.8
申请日：2015-10-16
CPC分类号： A61K9/1273
摘要： The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
摘要翻译： 本公开涉及包含至少一个亲水部分和至少一个疏水部分的层，该层包含在层的亲水部分和疏水部分上彼此聚合的自组装两亲分子; 检测装置，包括基板和上述层; 和脂质体，胶束，物质输送系统和包含上述层的仿生系统。 本公开还涉及一种生产层的方法，该方法包括：提供两亲分子; 允许足够的时间使两亲分子自组装并形成至少一个亲水部分和该层的至少一个疏水部分; 在层的亲水部分和疏水部分上彼此聚合自组装的两亲性分子。
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公开(公告)号：EP4004943A1
公开(公告)日：2022-06-01
申请号：EP20742742.8
申请日：2020-07-22
发明人： JIRSA, Viktor , SIP, Viktor
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6.发明公开
公开(公告)号：EP3745415A1
公开(公告)日：2020-12-02
申请号：EP19176827.4
申请日：2019-05-27
发明人： AN, Sora , JIRSA, Viktor
IPC分类号： G16H50/50
摘要： The invention relates to a method of identifying a potentially surgically operable target zone in an epileptic patient's brain. According to the invention, the method comprises the following steps: providing a computerized platform modelling various zones of a primate brain and connectivity between said zones; providing a model of an epileptogenic zone and a model of the propagation of an epileptic discharge from an epileptic zone to a propagation zone; obtaining a patient's personalized computerized platform; deriving the potential target zones based on modularity analysis; evaluating the target zones' effectiveness by simulating epileptic seizures propagation in the personalized patient's computerized platform; evaluating the target zones' safety by simulating spatiotemporal brain activation patterns in a defined state condition and comparing the simulated spatiotemporal brain activation patterns obtained before removal of the target zone with the spatiotemporal brain activation patterns obtained after removal of the target zone; identifying the target zones which satisfy both effectiveness and safety evaluation criteria as potentially surgically operable target zones.
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7.发明授权
公开(公告)号：EP3422935B1
公开(公告)日：2020-10-28
申请号：EP17707337.6
申请日：2017-02-28
申请人： Universite d'Aix-Marseille (AMU) , Institut National de la Santé et de la Recherche Médicale , Assistance Publique - Hôpitaux de Marseille (AP-HM)
IPC分类号： A61B5/0476 , A61B5/048
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公开(公告)号：EP3362050A1
公开(公告)日：2018-08-22
申请号：EP16790527.2
申请日：2016-10-13
CPC分类号： A61K9/1273
摘要： The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
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公开(公告)号：EP4003694A1
公开(公告)日：2022-06-01
申请号：EP20740645.5
申请日：2020-07-22
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite d'Aix-Marseille (AMU) , Ecole Centrale de Marseille
IPC分类号： B29C64/106 , B29C64/135 , B33Y70/00 , B33Y10/00 , B33Y30/00 , G03F7/00 , G03F7/027
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公开(公告)号：EP3770918A1
公开(公告)日：2021-01-27
申请号：EP19187615.0
申请日：2019-07-22
发明人： JIRSA, Viktor , SIP, Viktor
摘要： The invention relates to method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain. The method according to the invention comprises the steps of providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.
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