利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

241 条记录 (耗时 0.029 秒)

    IMPROVED MAGNETICALLY REACTIVE VESICULAR BODIES
    4.
    发明公开
    IMPROVED MAGNETICALLY REACTIVE VESICULAR BODIES 审中-公开
    VERBESSERTE，MAGNETISCH REECTIVEVESIKULÄREKÖRPER

    公开(公告)号：EP3162361A1

    公开(公告)日：2017-05-03

    申请号：EP15192570

    申请日：2015-11-02

    申请人： UNIVERSITÄT FÜR BODENKULTUR WIEN

    发明人： BIXNER OLIVER ,  SHIRMARDI SHAGHASEMI BEHZAD ,  REIMHULT ERIK

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1273 ,  A61K9/5094 ,  A61K41/0028

    摘要： The invention provides a method of preparing a vesicular particle having at least in part a lipid and/or polymeric membrane that is a barrier between the interior and exterior of said vesicular particle, wherein said membrane comprises at least one inorganic core nanoparticle embedded in said membrane, said method comprises the steps of i) providing a first dispersion with one or more inorganic core particles having a hydrophobic dispersant shell, in a solution of membrane forming lipids and/or polymers in a non-aqueous solvent; and ii) introducing the first dispersion into a non-solvent for the membrane forming lipids and/or polymers, wherein the volume of the non-solvent exceeds the volume of the first dispersion, thereby forming the vesicular particles; the produced particle preparations and their uses.

    摘要翻译： 本发明提供了一种制备至少部分具有作为所述囊泡颗粒的内部和外部之间的屏障的脂质和/或聚合物膜的囊泡颗粒的方法，其中所述膜包含至少一种嵌入所述膜中的无机核心纳米颗粒 所述方法包括以下步骤：i）在膜形成脂质和/或聚合物在非水性溶剂中的溶液中提供具有一种或多种具有疏水性分散剂壳的无机芯颗粒的第一分散体; 和ii）将第一分散体引入用于形成膜的脂质和/或聚合物的非溶剂中，其中非溶剂的体积超过第一分散体的体积，从而形成囊泡颗粒; 生产的颗粒制剂及其用途。

    AMPHIPHILIC MOLECULES LAYERS
    5.
    发明公开
    AMPHIPHILIC MOLECULES LAYERS 审中-公开
    AMPHIPHILEMOLEKÜLSCHICHTEN

    公开(公告)号：EP3156046A1

    公开(公告)日：2017-04-19

    申请号：EP15306656.8

    申请日：2015-10-16

    申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- ,  Universite d'Aix-Marseille (AMU)

    发明人： KENAAN, Ahmad ,  CHARRIER, Anne Magali ,  LAVANDIER, Sébastien ,  RAIMUNDO, Jean-Manuel

    IPC分类号： A61K9/127 ,  H01L29/00

    CPC分类号： A61K9/1273

    摘要： The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.

    摘要翻译： 本公开涉及包含至少一个亲水部分和至少一个疏水部分的层，该层包含在层的亲水部分和疏水部分上彼此聚合的自组装两亲分子; 检测装置，包括基板和上述层; 和脂质体，胶束，物质输送系统和包含上述层的仿生系统。 本公开还涉及一种生产层的方法，该方法包括：提供两亲分子; 允许足够的时间使两亲分子自组装并形成至少一个亲水部分和该层的至少一个疏水部分; 在层的亲水部分和疏水部分上彼此聚合自组装的两亲性分子。

    LIPOSOME COMPOSITION FOR USE IN PERITONEAL DIALYSIS
    9.
    发明公开
    LIPOSOME COMPOSITION FOR USE IN PERITONEAL DIALYSIS 审中-公开
    LIPOSOMENZUSAMMENSETZUNGFÜRPERITONEALDIALYSE

    公开(公告)号：EP2882421A1

    公开(公告)日：2015-06-17

    申请号：EP13745798.2

    申请日：2013-08-06

    申请人： ETH Zurich

    发明人： LEROUX, Jean-Christophe ,  FORSTER, Vincent

    IPC分类号： A61K9/127 ,  A61P7/08

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1273 ,  A61M1/287

    摘要： The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The inventtion also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.

    摘要翻译： 本发明涉及一种脂质体组合物，用于患有内源性或外源性毒性病症的患者的腹膜透析，其中脂质体内的pH与腹膜腔内的pH不同，并且其中脂质体内的pH导致脂质体包封的带电 毒素。 本发明还涉及包含所述脂质体的药物组合物。 本发明的另一方面涉及一种治疗患有内源性或外源性毒性病，优选选自药物，代谢物，杀虫剂，杀虫剂，毒素和化学战毒物性疾病，更优选高氨血症的患者的方法，所述方法包括以下步骤： 本发明以治疗有效量进入有需要的患者的腹膜空间。 在人的旁边，本发明特别适用于兽医方面。