公开(公告)号：EP2050035A2

公开(公告)日：2009-04-22

申请号：EP07810823.0

申请日：2007-07-25

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency (BCCA) ,  Catalan Institute of Oncology ,  Rikshospitalet-RadiumHospitalet Medical Center ,  St. Bartholomew's Hospital ,  University of Arizona Cancer Center ,  University of Barcelona ,  University of Nebraska Medical Center ,  University of Rochester Medical Center ,  University of Würzburg ,  Powell, John I.

发明人： STAUDT, Louis M. ,  WRIGHT, George ,  DAVE, Sandeep ,  TAN, Bruce ,  WILSON, Wyndham ,  JAFFE, Elaine ,  CHAN, Wing C. ,  GREINER, Timothy C. ,  WEISSENBURGER, Dennis ,  ARMITAGE, James ,  FU, Kai ,  FISHER, Richard ,  RIMSZA, Lisa ,  MILLER, Thomas ,  GROGAN, Thomas ,  CAMPO, Elias ,  BEA, Silvia M. ,  SALAVERRIA, Itziar ,  LOPEZ-GUILLERMO, Armando ,  MONTSERRAT, Emili ,  MORENO, Victor ,  ZETTL, Andreas ,  OTT, German ,  MULLER-HERMELINK, Hans-Konrad ,  ROSENWALD, Andreas ,  VOSE, Julie ,  GASCOYNE, Randy ,  CONNORS, Joseph ,  SMELAND, Erlend ,  KVALOY, Stein ,  HOLTE, Harald ,  DELABIE, Jan ,  LISTER, T. Andrew

IPC分类号： G06F19/00 ,  C12Q1/68

CPC分类号： G01N33/6842 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/51 ,  G06F19/20 ,  G06F19/24 ,  Y02A90/26

摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

公开(公告)号：EP2299377A1

公开(公告)日：2011-03-23

申请号：EP10014565.5

申请日：2007-07-25

申请人： The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services ,  British Columbia Cancer Agency (BCCA) ,  Catalan Institute of Oncology ,  Rikshospitalet-RadiumHospitalet Medical Center ,  St. Bartholomew's Hospital ,  University of Arizona Cancer Center ,  University of Barcelona ,  University of Nebraska Medical Center ,  University of Rochester Medical Center ,  University of Würzburg ,  Powell, John I.

发明人： Staudt, Luis M ,  Wright, George ,  Sandeep, Dave ,  Tan, Bruce ,  Wyndham, Wilson ,  Jaffe, Elaine ,  Wing, C Chan ,  Greiner, Timothy C ,  Weisenburger, Dennis ,  Armitage, James ,  Fu, Kai ,  Fisher, Richard I ,  Rimsza, Lisa ,  Miller, Thomas ,  Grogan, Thomas ,  Campo, Elias ,  Bea, Silvia M ,  Salaverria, Itziar ,  Lopez-Guillermo, Armando ,  Powell, John I ,  Montserrat, Emilio ,  Moreno, Victor ,  Zettl, Andreas ,  Ott, German ,  Muller-Hermelink, Hans-Konrad ,  Rosenwald, Andreas ,  Vose, Julie ,  Gascoyne, Randy ,  Connors, Joseph ,  Smeland, Erlend ,  Kvaloy, Stein ,  Holte, Harald ,  Delabie, Jan ,  Lister, T Andrew

IPC分类号： G06F19/20 ,  G06F19/24 ,  C12Q1/68

CPC分类号： G01N33/6842 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/51 ,  G06F19/20 ,  G06F19/24 ,  Y02A90/26

摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

摘要翻译： 基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。 此外，基因表达数据可用于开发更准确的生存预测因子。 本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴增生性疾病存活的方法。 本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。 本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。 该信息将有助于开发与特定受试者一起使用的治疗方法。

公开(公告)号：EP0942755A2

公开(公告)日：1999-09-22

申请号：EP97951144.0

申请日：1997-11-07

申请人： The Autonomous University of Barcelona

发明人： BOSCH, Fatima ,  VALERA, Alfons

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P1 ,  A61P3 ,  A61P5 ,  A61P21

CPC分类号： A61K38/1709 ,  A61K48/00

摘要： The invention features a process of treating a diabetic patient, which comprises the step of administering to said patient a DNA segment which includes a transcription factor gene and a promoter sequence, said promoter sequence being operably linked to said transcription factor and being effective for the expression of a therapeutically effective amount of the transcription factor in said patient.