公开(公告)号：EP2050035A2

公开(公告)日：2009-04-22

申请号：EP07810823.0

申请日：2007-07-25

申请人： Government of the United States of America, Represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency (BCCA) ,  Catalan Institute of Oncology ,  Rikshospitalet-RadiumHospitalet Medical Center ,  St. Bartholomew's Hospital ,  University of Arizona Cancer Center ,  University of Barcelona ,  University of Nebraska Medical Center ,  University of Rochester Medical Center ,  University of Würzburg ,  Powell, John I.

发明人： STAUDT, Louis M. ,  WRIGHT, George ,  DAVE, Sandeep ,  TAN, Bruce ,  WILSON, Wyndham ,  JAFFE, Elaine ,  CHAN, Wing C. ,  GREINER, Timothy C. ,  WEISSENBURGER, Dennis ,  ARMITAGE, James ,  FU, Kai ,  FISHER, Richard ,  RIMSZA, Lisa ,  MILLER, Thomas ,  GROGAN, Thomas ,  CAMPO, Elias ,  BEA, Silvia M. ,  SALAVERRIA, Itziar ,  LOPEZ-GUILLERMO, Armando ,  MONTSERRAT, Emili ,  MORENO, Victor ,  ZETTL, Andreas ,  OTT, German ,  MULLER-HERMELINK, Hans-Konrad ,  ROSENWALD, Andreas ,  VOSE, Julie ,  GASCOYNE, Randy ,  CONNORS, Joseph ,  SMELAND, Erlend ,  KVALOY, Stein ,  HOLTE, Harald ,  DELABIE, Jan ,  LISTER, T. Andrew

IPC分类号： G06F19/00 ,  C12Q1/68

CPC分类号： G01N33/6842 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/51 ,  G06F19/20 ,  G06F19/24 ,  Y02A90/26

摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.