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公开(公告)号：EP4242679A1
公开(公告)日：2023-09-13
申请号：EP22305258.0
申请日：2022-03-07
申请人： Wainvam-E
IPC分类号： G01R33/32 , G01R33/26 , G01N24/00 , G01R33/032
摘要： A source of fluorescence is described. The source of fluorescence shaped as a diamond waveguide comprising defects in a diamond configured to emit a fluorescence when submitted to an excitation light provided by a source of excitation, and an inlet through which said excitation light is arranged to be introduced, wherein said diamond waveguide has an elongated shape and is arranged to couple said excitation light and said defects through the length of the diamond waveguide. Sensor devices comprising said source of fluorescence is also disclosed. A magnetometer comprising said sensor device is also disclosed.
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公开(公告)号：EP4224185A1
公开(公告)日：2023-08-09
申请号：EP22305121.0
申请日：2022-02-03
申请人： Wainvam-E
IPC分类号： G01R33/00 , G01R33/032 , G01R33/20 , G01R33/26
摘要： The invention relates to a sensor assembly (10) comprising a mounting support (20) anda nitrogen-vacancy diamond (12) connected to at least one optical fiber (22), said mounting support (20) comprising:
- a support element (30) having a bottom surface (32) defining a reference plane (P2), and having, at a front end, a socket (36) designed to receive the nitrogen-vacancy diamond (12) in a predetermined angular position (a1) allowing predetermined alignment of its nitrogen-vacancy axis with regards to the reference plane (P2), said socket (36) comprising a recess (40) for housing said nitrogen-vacancy diamond (12) in the predetermined angular position (a1), and
- a holder element (50) which is mounted on the support element (30), and which comprises a guiding surface (52) to guide and bend the optical fiber (22) from the nitrogen-vacancy diamond (12) to a rear portion of the holder element (50).-
公开(公告)号：EP4379364A1
公开(公告)日：2024-06-05
申请号：EP22306771.1
申请日：2022-12-01
申请人： Wainvam-E
发明人： BEATO, François , GEIGER, Remi , HINGANT, Thomas
CPC分类号： G01R33/323 , G01N24/10 , G01R33/24
摘要： A device and method for measuring a first magnetic field are described. The method comprises:
- applying (S401) an oscillating excitation magnetic field to a diamond (901) comprising nitrogen-vacancy centers, the magnetic field having an amplitude (BOSC);
- exposing the nitrogen-vacancy centers to the first magnetic field;
- applying (S402) a microwave signal to the diamond; illuminating the diamond using green light for causing the nitrogen-vacancy centers to emit a fluorescence;
wherein the amplitude of the oscillating magnetic field is sufficiently high to cause resonances in the fluorescence at the microwave signal frequency or at harmonics of the microwave signal frequency;
- determining (S403) a timing of the resonances;
- obtaining (S404) a measurement of the first magnetic field as a function of the timing of the resonances.-
4.发明公开
公开(公告)号：EP4306957A1
公开(公告)日：2024-01-17
申请号：EP22306034.4
申请日：2022-07-11
申请人： Wainvam-E
发明人： PERRE, Agathe , LE GUEVELLO, Morgane , RANI, Dipti
IPC分类号： G01N33/543 , G01N33/50 , G01N33/53 , G01N33/551 , G01N33/94
摘要： The present invention relates to a method for quantitative measurement of antibiotics in a sample, comprising the steps of:
(1) Functionalizing nanodiamonds having Nitrogen-Vacancy (NV) centers with ligands able to bind specifically to said antibiotics,
(2) Bringing said functionalized nanodiamonds into contact with said antibiotics, under conditions allowing binding between said nanodiamond and said antibiotics,
(3) Illuminating the NV centers with green light, and
(4) Measuring red fluorescence emitted by the NV centers, wherein the amount of red fluorescence emitted by the NV centers is proportional to the amount of nanodiamonds bound to the antibiotics.
The present invention also relates to a carboxylated nanodiamond having Nitrogen-Vacancy (NV) centers, which is functionalized with monoclonal antibodies that are able to bind specifically to antibiotics, and to a device comprising a processor and memory, said memory comprising code that, when executed by said processor, causes the device to perform the method of the invention.
The present invention further relates to the use of the method as defined above, or of a functionalized nanodiamond as defined above, for quantitative measurement of antibiotics in the food industry, in water treatment, in aquaculture or in farming.
Finally, the invention relates to a method for preparing a carboxylated nanodiamond having Nitrogen-Vacancy (NV) centers, which is functionalized with monoclonal antibodies that are able to bind specifically to an antibiotic.-
5.发明公开
公开(公告)号：EP4286849A1
公开(公告)日：2023-12-06
申请号：EP22305813.2
申请日：2022-06-03
申请人： Wainvam-E
发明人： LE GUEVELLO, Morgane , RANI, Dipti
IPC分类号： G01N33/543 , G01N33/50 , G01N33/53 , G01N33/551
摘要： The present invention relates to a method for quantitative measurement of reducing sugars in a sample, comprising the steps of:
(1) Functionalizing nanodiamonds having NV centers with ligands able to bind specifically to said reducing sugars,
(2) Bringing said functionalized nanodiamonds into contact with said reducing sugars, under conditions allowing binding between said nanodiamond and said reducing sugars,
(3) Illuminating the NV centers with green light, and
(4) Measuring red fluorescence emitted by the NV centers,
wherein the amount of red fluorescence emitted by the NV centers is proportional to the amount of nanodiamonds bound to the reducing sugars.
The present invention also relates to a carboxylated nanodiamond having NV centers, which is functionalized with aptamers or with polyclonal antibodies that are able to bind specifically to said reducing sugars, and to a device comprising a processor and memory, said memory comprising code that, when executed by said processor, causes the device to perform the method of the invention.
The present invention further relates to the use of the method as defined above, or of a functionalized nanodiamond as defined above, for quantitative measurement of reducing sugars in the food industry.
Finally, the invention relates to a method for preparing a carboxylated nanodiamond having NV centers, which is functionalized with aptamers that are able to bind specifically to said reducing sugars.-
公开(公告)号：EP4060339A1
公开(公告)日：2022-09-21
申请号：EP21305744.1
申请日：2021-06-03
申请人： Wainvam-E
IPC分类号： G01N33/533 , B82Y30/00 , G01N21/27
摘要： The present invention relates to a method for assessing antioxidant efficacy of one or more molecule(s) introduced inside or in the vicinity of a cell by measuring, in said cell, free radical concentration, the method comprising the steps of:
- Functionalizing nanodiamonds having Nitrogen-Vacancy (NV) centers with species able to target an organelle within the cell,
- Introducing the functionalized nanodiamonds inside the cell,
- Illuminating NV centers with green light, and
- Measuring red fluorescence of the NV centers in the cell after the action of the molecule(s), and also optionally before and/or during the action of the molecule(s),
wherein red fluorescence of the NV centers depends on the free radical concentration in the cell.
The present invention also relates to a nanodiamond (ND) having Nitrogen-Vacancy (NV) centers with species able to target an organelle within a cell, said species being chosen as COOH terminating said nanodiamonds linked covalently via amide linkage either with transactivating transcriptional activator (TAT) peptide or with triphenyl phosphonium (TPP) tags.
The present invention further relates to a process for preparing the nanodiamond (ND), and to the use of the nanodiamond (ND) for sensing qualitatively or quantitatively free radicals in a cell sample.-
7.发明公开
公开(公告)号：EP4389850A1
公开(公告)日：2024-06-26
申请号：EP22306929.5
申请日：2022-12-19
申请人： Wainvam-E
CPC分类号： C09K11/65 , C09K11/025 , G01R33/60 , G01N24/10
摘要： The present invention relates to a nanodiamond having Nitrogen-Vacancy (NV) centers, which is functionalized with a linker bond to a spin trap.
It also relates to an in vitro method for detecting and/or quantifying biological free radicals in a sample, and to the use of a nanodiamond of the invention for assessing antioxidant efficacy of a molecule in a sample, or for detecting and/or quantifying biological free radicals in a sample.
The present invention also concerns the use of the nanodiamond for monitoring a disease in which free radicals are involved, by detecting and/or quantifying biological free radicals in a biological sample of a patient.-
公开(公告)号：EP4370911A1
公开(公告)日：2024-05-22
申请号：EP22741302.8
申请日：2022-07-11
申请人： Wainvam-E
CPC分类号： G01N27/82 , G01N27/83 , G01R33/26 , G01R33/323
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公开(公告)号：EP4224187A1
公开(公告)日：2023-08-09
申请号：EP22305123.6
申请日：2022-02-04
申请人： Wainvam-E
发明人： BEATO, François , HINGANT, Thomas
摘要： A device and method for measuring a physical parameter are described. The device comprises a signal generator (68) for generating a signal representative of a fluorescence (67) emitted by nitrogen-vacancy centers of a diamond in response to excitation by a source of light (66). The device further comprises:
- a first microwave generator (61, 73) for generating a first microwave signal at a first frequency (f_MW,av, f'_MW,av) and a second microwave (62, 74) generator for generating a second microwave signal at a second frequency (f_MW,d, f'_MW,d), one of said first and second frequencies having been modulated at a third frequency (f_mod); wherein respective initial values of said first and second frequencies are such that the sum and the difference of said second and first frequencies are substantially equal to respective estimates of a first and a second resonance frequency of said nitrogen-vacancy centers;
- a signal processing circuit (53, 63) for combining said first and second microwave signals to obtain a third microwave signal comprising frequencies corresponding to the sum and the difference of said first and second frequencies and for providing said third microwave signal to a radiating component (64) configured to provide microwaves to said nitrogen-vacancy centers;
- a demodulator (69) for demodulating the signal representative of said fluorescence at said third frequency (f_mod);
- a processor (75) for determining said physical parameter measurement as a function of said demodulated signal.-
10.发明公开
公开(公告)号：EP4194874A1
公开(公告)日：2023-06-14
申请号：EP21306733.3
申请日：2021-12-09
申请人： Wainvam-E
摘要： A sensor device is described. The sensor device comprises a source of fluorescence (1201, 1202, 1301, 1302), wherein said fluorescence is function of a physical phenomenon to be sensed and wherein said fluorescence is generated in response to an excitation provided by a source of excitation; a collector (1203, 1303) for collecting said fluorescence; a reflector (1210, 1310) placed around said source of fluorescence to reflect said fluorescence towards said collector, wherein said reflector is provided with an opening at its vertex, the source of fluorescence being arranged within said reflector to sense said physical phenomenon through said opening. A magnetometer comprising said sensor device is also disclosed.
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