公开(公告)号：EP2356457B1

公开(公告)日：2018-05-16

申请号：EP08875824.8

申请日：2008-10-13

申请人： Xeptagen SPA

发明人： PENGO, Paolo ,  BENEDUCE, Luca ,  FASSINA, Giorgio

IPC分类号： G01N33/543

CPC分类号： G01N33/54386 ,  G01N33/54393

摘要： The present invention concerns a method for the preparation of molecular conjugates comprising immunoglobulins and biomarkers occurring in neoplastic diseases characterized by high levels of reproducibility.

公开(公告)号：EP2367005A1

公开(公告)日：2011-09-21

申请号：EP10178983.2

申请日：2004-10-26

申请人： Xeptagen SPA

发明人： Beneduce, Luca ,  Marino, Maria ,  Pontisso, Patrizia ,  Fassina, Giorgio

IPC分类号： G01N33/574

CPC分类号： G01N33/57419 ,  G01N33/57473

摘要： This invention relates to a method for diagnosis of cancer based on the qualitative and quantitative detection of specific circulating immune complexes constituted by tumor associated antigen/ specific autoantibody.

摘要翻译： 本发明涉及一种基于由肿瘤相关抗原/特异性自身抗体构成的特异性循环免疫复合物的定性和定量检测的癌症诊断方法。

公开(公告)号：EP2766729B1

公开(公告)日：2018-12-05

申请号：EP12780857.4

申请日：2012-10-11

申请人： Xeptagen SPA

发明人： FASSINA, Giorgio ,  GALLOTTA, Andrea

IPC分类号： G01N33/564 ,  G01N33/574

CPC分类号： G01N33/564 ,  G01N33/57434 ,  G01N2800/342

摘要： It is a method to diagnose the presence of prostate cancer including the steps of: (a) determination of the quantity of PSA-IgM occurring in a biological sample of the subject, (b) determination of the quantity of total PSA occurring in a biological sample of the subject, (c) determination of the quantity of free PSA occurring in a biological sample of the subject, (d) determination of the prostate volume of the subject, and (e) definition of the age of the subject; (f) correlation of the presence or absence of prostate cancer in the subject under examination with a value predetermined and established with patients samples diagnosed with prostate cancer or benign disease known on the basis of the mathematical combination of all or some of the quantities listed in points a. b. c. d. e.

公开(公告)号：EP2766729A1

公开(公告)日：2014-08-20

申请号：EP12780857.4

申请日：2012-10-11

申请人： Xeptagen SPA

发明人： FASSINA, Giorgio ,  GALLOTTA, Andrea

IPC分类号： G01N33/574 ,  G01N33/68

CPC分类号： G01N33/564 ,  G01N33/57434 ,  G01N2800/342

摘要： It is a method to diagnose the presence of prostate cancer including the steps of: (a) determination of the quantity of PSA-IgM occurring in a biological sample of the subject, (b) determination of the quantity of total PSA occurring in a biological sample of the subject, (c) determination of the quantity of free PSA occurring in a biological sample of the subject, (d) determination of the prostate volume of the subject, and (e) definition of the age of the subject; (f) correlation of the presence or absence of prostate cancer in the subject under examination with a value predetermined and established with patients samples diagnosed with prostate cancer or benign disease known on the basis of the mathematical combination of all or some of the quantities listed in points a. b. c. d. e.

摘要翻译： 这是一种诊断前列腺癌存在的方法，包括以下步骤：（a）确定在受试者的生物样品中发生的PSA-IgM的量，（b）确定在生物学中发生的总PSA的量 受试者的样本，（c）测定受试者生物样品中游离PSA的量，（d）确定受试者的前列腺体积，以及（e）对受试者年龄的定义; （f）正在检查的受试者中前列腺癌的存在或不存在与预先确定的和与诊断为患有前列腺癌或良性疾病的患者样品建立的值相关联，所述患者样品是基于所有或部分所列数量的数学组合而已知的 点a。 湾 C。 天。 即

公开(公告)号：EP2356457A1

公开(公告)日：2011-08-17

申请号：EP08875824.8

申请日：2008-10-13

申请人： Xeptagen SPA

发明人： PENGO, Paolo ,  BENEDUCE, Luca ,  FASSINA, Giorgio

IPC分类号： G01N33/543

CPC分类号： G01N33/54386 ,  G01N33/54393

摘要： The present invention concerns a method for the preparation of molecular conjugates comprising immunoglobulins and biomarkers occurring in neoplastic diseases characterized by high levels of reproducibility.

摘要翻译： 本发明涉及一种制备分子结合物的方法，其包含以高水平重现性为​​特征的肿瘤疾病中发生的免疫球蛋白和生物标志物。

公开(公告)号：EP2339345A1

公开(公告)日：2011-06-29

申请号：EP10182565.1

申请日：2004-10-26

申请人： Xeptagen SPA

发明人： Beneduce, Luca ,  Marino, Maria ,  Pontisso, Patrizia ,  Fassina, Giorgio

IPC分类号： G01N33/574

CPC分类号： G01N33/57419 ,  G01N33/57473

摘要： This invention relates to a method for diagnosis of cancer based on the qualitative and quantitative detection of specific circulating immune complexes constituted by tumor associated antigen/ specific autoantibody.

摘要翻译： 本发明涉及一种基于由肿瘤相关抗原/特异性自身抗体构成的特异性循环免疫复合物的定性和定量检测的癌症诊断方法。