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公开(公告)号：EP1678503B1
公开(公告)日：2012-05-09
申请号：EP04791917.0
申请日：2004-10-26
申请人： Xeptagen S.p.A.
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/57473
摘要： This invention relates to a method for diagnosis of cancer based on the qualitative and quantitative detection of specific circulating immune complexes constituted by tumor associated antigen/ specific autoantibody.
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2.发明公开Method for measuring values indicating cancer 审中-公开Verfahren zum Messen von Werten，die auf Krebs hinweisen
公开(公告)号：EP2367005A1
公开(公告)日：2011-09-21
申请号：EP10178983.2
申请日：2004-10-26
申请人： Xeptagen SPA
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/57473
摘要： This invention relates to a method for diagnosis of cancer based on the qualitative and quantitative detection of specific circulating immune complexes constituted by tumor associated antigen/ specific autoantibody.
摘要翻译： 本发明涉及一种基于由肿瘤相关抗原/特异性自身抗体构成的特异性循环免疫复合物的定性和定量检测的癌症诊断方法。
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公开(公告)号：EP1934373A4
公开(公告)日：2009-04-29
申请号：EP06803659
申请日：2006-09-14
申请人： UNIV CALIFORNIA
发明人： WONG DAVID T W , BROOKS MAI NGUYEN
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N33/57496 , G01N2333/475 , G01N2333/485 , G01N2800/52
摘要： The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva.
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公开(公告)号：EP1934373A2
公开(公告)日：2008-06-25
申请号：EP06803659.9
申请日：2006-09-14
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N33/57496 , G01N2333/475 , G01N2333/485 , G01N2800/52
摘要： The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva.
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5.发明授权USE OF PROTEIN CELLULAR RETINOIC ACID-BINDING PROTEIN II (CRABP II) AS MARKER FOR BREAST CANCER 有权中蛋白质CRABP II（CELLULAR视黄酸结合蛋白II）作为标志物用于乳腺癌USE
公开(公告)号：EP1636584B1
公开(公告)日：2007-04-11
申请号：EP04739585.0
申请日：2004-06-04
发明人： PESTLIN, Gabriele , ANDRES, Herbert , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid-binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid-binding protein II in said sample. Measurement of cellular retinoic acid-binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.
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公开(公告)号：EP1678503A2
公开(公告)日：2006-07-12
申请号：EP04791917.0
申请日：2004-10-26
申请人： Xeptagen S.p.A.
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/57473
摘要： This invention relates to a method for diagnosis of cancer based on the qualitative and quantitative detection of specific circulating immune complexes constituted by tumor associated antigen/ specific autoantibody.
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公开(公告)号：EP1436613A1
公开(公告)日：2004-07-14
申请号：EP02785494.2
申请日：2002-09-11
申请人： Endogenics
IPC分类号： G01N33/50
CPC分类号： C12Q1/50 , C12Q1/32 , C12Q1/42 , G01N33/5094 , G01N33/56972 , G01N33/57473 , G01N33/721 , G01N33/80 , G06F19/00
摘要： The invention concerns a method for evaluating a patient's dynamic biological condition, said method, which comprises measuring several elements or substances contained in the blood and interpreting the results of the measurements carried out, being characterized in that it comprises the following steps: (1) taking a sample of blood from the patient to be examined; (2) determining hematic substances serving as metabolic and/or tissue parameters; (3) measuring, on the basis of the determination at step (2), the totality or part of the indicators J1 to J157 defined in the description, and (4) comparing at least part of said indicators J1 to J157 with similar values obtained at steps (2) and (3) on subjects already identified as healthy, to dynamically assess the biological condition of the patient to be examined. The invention also concerns a software product for executing on a computer steps (3) and (4).
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公开(公告)号：EP1169479A2
公开(公告)日：2002-01-09
申请号：EP00921839.7
申请日：2000-04-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , G01N33/57419 , G01N33/57473
摘要： The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.
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9.发明公开A method for detection of carcinoembryonic antigens having a modified sugar chain structure 审中-公开一种用于检测癌胚抗原的具有修饰的糖链结构的方法
公开(公告)号：EP1061370A3
公开(公告)日：2001-05-30
申请号：EP00112207.6
申请日：2000-06-07
IPC分类号： G01N33/574
CPC分类号： G01N33/57473 , G01N2400/02
摘要： The present invention relates to a method for detection of carcinoembryonic antigens (hereinafter abbreviated as CEAs) having a modified sugar chain structure which comprises using an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs, a method for detecting a cancer which comprises using an amount of CEAs having a modified sugar chain structure and a kit for detection of CEAs having a modified sugar chain structure which comprises an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs. Said method and kit are useful in a separately measurement of the various CEAs, a detection of a cancer and a definition of the kind of a cancer, and, for example, by using in proper combination of the measurement value of various CEAs obtained by the method of the present invention, it becomes possible to detect the cancer or define the kind of the cancer.
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10.发明公开A method for detection of carcinoembryonic antigens having a modified sugar chain structure 审中-公开一种用于检测癌胚抗原的具有修饰的糖链结构的方法
公开(公告)号：EP1061370A2
公开(公告)日：2000-12-20
申请号：EP00112207.6
申请日：2000-06-07
IPC分类号： G01N33/574
CPC分类号： G01N33/57473 , G01N2400/02
摘要： The present invention relates to a method for detection of carcinoembryonic antigens (hereinafter abbreviated as CEAs) having a modified sugar chain structure which comprises using an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs, a method for detecting a cancer which comprises using an amount of CEAs having a modified sugar chain structure and a kit for detection of CEAs having a modified sugar chain structure which comprises an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs.
Said method and kit are useful in a separately measurement of the various CEAs, a detection of a cancer and a definition of the kind of a cancer, and, for example, by using in proper combination of the measurement value of various CEAs obtained by the method of the present invention, it becomes possible to detect the cancer or define the kind of the cancer.摘要翻译： 本发明涉及一种用于检测癌胚抗原的方法（在后缩写为CEA）具有包括使用抗体对CEA的恒定区，并且能够认识到CEAS的经修饰的糖链结构的蛋白，其修饰的糖链结构，一个 用于检测包括使用达CEAS的具有修饰的糖链结构和用于检测CEAS的具有修饰的糖链结构，其抗体对CEA的恒定区和蛋白包含能够识别经修饰的糖的试剂盒的癌症的方法 CEAS的链结构。 所述方法和试剂盒是在一个单独的测量的各种CEAS，癌症的检测和种类的癌症的定义，是有用的，并且，例如，通过使用由所述获得的各种CEAS的测量值的适当组合 本发明的方法，能够检测出癌症或限定的种类，癌症的。
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