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公开(公告)号：EP1490387A2
公开(公告)日：2004-12-29
申请号：EP03721470.7
申请日：2003-03-25
申请人： Yen, Yun
发明人： Yen, Yun
CPC分类号： C12N9/0093 , A61K38/00
摘要： An isolated nucleic acid containing a human ribonucleotide reductase M2 subunit promoter sequence or genomic sequence. Also disclosed are methods of determining whether a subject is suffering from or at risk for developing a cell proliferation-associated disorder, identifying a compound for treating a cell proliferation-associated disorder, treating a cell proliferation-associated disorder, and developing a procedure for treating a cell proliferation-associated disorder.
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公开(公告)号：EP1573063A4
公开(公告)日：2006-12-13
申请号：EP03788403
申请日：2003-08-12
申请人： YEN YUN
发明人： YEN YUN
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
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公开(公告)号：EP3129373A4
公开(公告)日：2017-11-29
申请号：EP15776965
申请日：2015-04-09
发明人： LIOU JING-PING , CHANG JANG-YANG , WANG JIA-YI , YEN YUN
IPC分类号： C07D471/04 , A61K31/404 , A61K31/416 , A61K31/437 , A61P35/00 , C07D209/08 , C07D231/56 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , C07D209/08 , C07D231/56 , C07D487/04
摘要： Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.
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4.发明公开
公开(公告)号：EP3324954A1
公开(公告)日：2018-05-30
申请号：EP15899099.4
申请日：2015-07-23
发明人： YEN, Yun , LIOU, Jing-ping , PAN, Shiow-lin
IPC分类号： A61K31/18 , A61K31/166 , A61K31/167
CPC分类号： C07D213/75 , A61K31/166 , A61K31/167 , A61K31/337 , A61K31/4409 , A61K31/475 , A61K31/506 , A61K31/593 , A61K31/704 , A61K33/24 , A61K2300/00 , A61P3/10 , A61P25/28 , A61P35/02 , A61P37/00 , C07D209/04 , C07D213/74 , C07D213/76 , C07D215/40 , C07D215/42 , C07D231/38 , C07D235/30 , C07D239/42 , C07D241/04 , C07D241/20 , C07D277/42 , C07D471/04 , C07D487/04
摘要： The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.
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公开(公告)号：EP3129373A1
公开(公告)日：2017-02-15
申请号：EP15776965.4
申请日：2015-04-09
发明人： LIOU, Jing-Ping , CHANG, Jang-Yang , WANG, Jia-Yi , YEN, Yun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , C07D209/08 , C07D231/56 , C07D487/04
摘要： Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.
摘要翻译： 本文所述的式（I）的熔融自行车吲哚，二氢吲哚，偶氮吲哚或偶氮二吲哚啉化合物。 还公开了这些化合物的药学上可接受的盐和含有它们的药物组合物。 进一步公开的是用这些化合物治疗癌症的方法，例如胶质瘤，前列腺癌和结肠直肠癌。
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公开(公告)号：EP1573063A2
公开(公告)日：2005-09-14
申请号：EP03788403.8
申请日：2003-08-12
申请人： Yen, Yun
发明人： Yen, Yun
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： A method of determining whether a subject is suffering from or at risk for developing a liver disease. The method includes providing a sample from the subject and determining a GADD45β expression level or a GADD45β activity level in the sample. If the GADD45β expression level or the GADD45β activity level in the sample is lower than that in a sample from a normal subject, it indicates that the subject is suffering from or at risk for developing a liver disease. Also disclosed are a method of identifying a compound for treating a liver disease and a method of treating such a disease.
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