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公开(公告)号：EP3129373A1
公开(公告)日：2017-02-15
申请号：EP15776965.4
申请日：2015-04-09
发明人： LIOU, Jing-Ping , CHANG, Jang-Yang , WANG, Jia-Yi , YEN, Yun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , C07D209/08 , C07D231/56 , C07D487/04
摘要： Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.
摘要翻译： 本文所述的式（I）的熔融自行车吲哚，二氢吲哚，偶氮吲哚或偶氮二吲哚啉化合物。 还公开了这些化合物的药学上可接受的盐和含有它们的药物组合物。 进一步公开的是用这些化合物治疗癌症的方法，例如胶质瘤，前列腺癌和结肠直肠癌。
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2.发明公开
公开(公告)号：EP3324954A1
公开(公告)日：2018-05-30
申请号：EP15899099.4
申请日：2015-07-23
发明人： YEN, Yun , LIOU, Jing-ping , PAN, Shiow-lin
IPC分类号： A61K31/18 , A61K31/166 , A61K31/167
CPC分类号： C07D213/75 , A61K31/166 , A61K31/167 , A61K31/337 , A61K31/4409 , A61K31/475 , A61K31/506 , A61K31/593 , A61K31/704 , A61K33/24 , A61K2300/00 , A61P3/10 , A61P25/28 , A61P35/02 , A61P37/00 , C07D209/04 , C07D213/74 , C07D213/76 , C07D215/40 , C07D215/42 , C07D231/38 , C07D235/30 , C07D239/42 , C07D241/04 , C07D241/20 , C07D277/42 , C07D471/04 , C07D487/04
摘要： The invention relates to new compounds with low cytotoxicity for blocking the ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders, autoimmune disorders and metabolic disorders.
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公开(公告)号：EP4399198A2
公开(公告)日：2024-07-17
申请号：EP22865863.9
申请日：2022-09-06
发明人： CHUANG, Kuo-Hsiang , LIOU, Jing-Ping , YEN, Yun
IPC分类号： C07C39/04 , C07C259/06 , C07C259/04 , A61P35/00
CPC分类号： C07D295/192 , C07C259/10 , C07D317/66 , A61P35/00 , A61K45/06 , A61K31/166 , A61K31/4745
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公开(公告)号：EP3402800A1
公开(公告)日：2018-11-21
申请号：EP17738972.3
申请日：2017-01-12
发明人： YEN, Yun , LIOU, Jing-Ping , LIU, Yun-Ru
IPC分类号： C07H15/207 , C07C235/84 , C07D213/81 , C07D401/04 , A61K31/381 , A61K31/4453 , A61K31/7034
CPC分类号： A61K31/381 , A61K31/4453 , A61K31/7034 , C07C235/64 , C07D211/58 , C07H15/203
摘要： The invention relates to compounds for inhibiting a cancer cell or a virus. Particularly, the invention provides compounds for inhibiting, treating and/or preventing cancer and Zika virus.
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5.发明公开
公开(公告)号：EP3328368A1
公开(公告)日：2018-06-06
申请号：EP16831462.3
申请日：2016-07-30
发明人： YEN, Yun , LIOU, Jing-ping , PAN, Shiow-lin
IPC分类号： A61K31/122 , C07C50/12
CPC分类号： C07D207/04 , A61K31/122 , A61K31/166 , A61K31/40 , A61K31/7048 , A61K33/24 , A61K45/06 , A61P3/10 , A61P25/14 , A61P25/28 , A61P35/00 , C07C225/30 , C07C235/54 , C07C237/34 , C07C237/48 , C07C255/58 , C07C311/29 , C07C2602/10 , C07D209/08 , C07D209/44 , C07D213/40 , C07D215/38 , C07D215/40 , C07D295/13 , C07D295/135 , A61K2300/00
摘要： The invention relates to new compounds with low cytotoxicity for blocking ubiquitination-proteasome system in diseases. Accordingly, these compounds can be used in treatment of treating disorders including, but not limited to, cancers, neurodegenerative diseases, inflammatory disorders and autoimmune disorders and metabolic disorders.
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公开(公告)号：EP3324970A1
公开(公告)日：2018-05-30
申请号：EP16828495.8
申请日：2016-07-20
发明人： YEN, Yun , LIOU, Jing-Ping , CHEN, Chun-Han
IPC分类号： A61K31/496 , A61K31/505 , C07D239/48
CPC分类号： A61K31/7068 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D239/42 , C07D239/48 , C07D401/02 , C07D405/02 , A61K2300/00
摘要： The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal cells. Particularly, the compounds of the invention have stronger inhibition effect on bladder cancer and liver cancer.
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公开(公告)号：EP3377062A1
公开(公告)日：2018-09-26
申请号：EP16867152.7
申请日：2016-11-17
发明人： YEN, Yun , LIOU, Jing-ping , LIN, Chien Huang
IPC分类号： A61K31/4409 , A61K31/122 , A61K31/166 , A61K31/426 , A61K9/20 , A61K9/48
CPC分类号： A61K31/166 , A61K9/0019 , A61K9/20 , A61K9/48 , A61K31/122 , A61K31/40 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4184 , A61K31/426 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/47 , A61K31/4706 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/519 , A61K31/5375 , A61K45/06 , A61P11/00 , C07C15/00
摘要： The invention relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.
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