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公开(公告)号:EP3464574A1
公开(公告)日:2019-04-10
申请号:EP17729433.7
申请日:2017-06-02
申请人: (INSERM) Institut National de la Santé et de la Recherche Médicale , ICM - Institut du Cerveau et da la Moelle Epinière , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , SORBONNE UNIVERSITE , Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) , Assistance Publique - Hôpitaux de Paris
IPC分类号: C12N9/22 , C12N15/867 , C12N15/85
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2.
公开(公告)号:EP3046930A1
公开(公告)日:2016-07-27
申请号:EP14766503.8
申请日:2014-09-17
申请人: INSERM - Institut National de la Santé et de la Recherche Médicale , CEA , Université Paris Sud
IPC分类号: C07K14/005 , C12N15/86
CPC分类号: C12N15/86 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N9/1241 , C12N15/64 , C12N2740/16043 , C12N2740/16052 , C12N2740/16062 , C12N2740/16211 , C12N2800/30 , C12N2810/6081 , C12Y207/07
摘要: The present invention relates to a lentiviral vector wherein the expressed integrase protein comprises at least one point mutation consisting of the substitution of the aspartic acid residue at position 167 by an amino acid selected from the group consisting of histidine, arginine and lysine.
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