公开(公告)号：EP1811902A2

公开(公告)日：2007-08-01

申请号：EP05825628.0

申请日：2005-11-15

申请人： (OSI) Eyetech, Inc.

发明人： SHIMA, David, T. ,  Ioannidou, Sofia ,  Robinson, Gregory S. ,  Xing, Heming

IPC分类号： A61B10/00 ,  G01N33/50

CPC分类号： G01N33/56966 ,  G01N33/5064 ,  G01N33/6803 ,  G01N33/6842

摘要： The invention relates to a plasma membrane marker for identifying fenestrae. The invention also relates to a method of visualizing fenestrae utilizing a plasma membrane marker and light microscopy. The invention also relates to a method of identifying a plasma membrane marker for fenestrae. In particular, the invention relates to the characterization of moesin as a component of fenestrae sieve plates. More particularly, the invention relates to the use of moesin as a plasma membrane marker. Moesin may be used as a plasma membrane marker for the identification of fenestrae or permeability of endothelial cells.