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公开(公告)号：EP4216750A1
公开(公告)日：2023-08-02
申请号：EP21871764.3
申请日：2021-09-15
发明人： NG, Lok-Man , MCCOY, Michael A. , NIWAS, Shri , XIA, Ying
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公开(公告)号：EP4038424A1
公开(公告)日：2022-08-10
申请号：EP20873329.5
申请日：2020-09-29
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公开(公告)号：EP3701300A1
公开(公告)日：2020-09-02
申请号：EP18871222.8
申请日：2018-10-25
发明人： CHEN-HO, Kui , GILMAN, Ann M. , GOTRIK, Kevin W. , JONES, Scott J. , LENTZ, Daniel M. , MCCOY, Michael A. , NIWAS, Shri , STAY, Matthew S. , KUDUVA RAMAN THANUMOORTHY, Ramasubramani , XIA, Ying
IPC分类号： G02B5/128
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公开(公告)号：EP1673087A2
公开(公告)日：2006-06-28
申请号：EP04794092.9
申请日：2004-10-01
发明人： LINDSTROM, Kyle, J. , MERRILL, Bryon, A. , HARALDSON, Chad, A. , RICE, Michael, J. , KSHIRSAGAR, Tushar, A. , HEPPNER, Philip, D. , WURST, Joshua, R. , NIWAS, Shri , JOHANNESSEN, Sarah, C.
IPC分类号： A61K31/4745 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/551 , C07D471/04 , C07D401/14 , C07D405/14 , A61P37/02
CPC分类号： C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
摘要： Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
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公开(公告)号：EP1658076A1
公开(公告)日：2006-05-24
申请号：EP04782492.5
申请日：2004-08-27
发明人： LINDSTROM, Kyle J., , MARTIN, Hugues , MERRILL, Bryon A., , RICE, Michael J., , WURST, Joshua R., , HARALDSON, Chad A., , KSHIRSAGAR, Tushar , HEPPNER, Philip D., , NIWAS, Shri , GRIESGRABER, George W., , RADMER, Matthew R.,
IPC分类号： A61K31/4745 , A61K31/5377 , C07D471/04 , C07D413/14
CPC分类号： C07D471/04
摘要： Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
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公开(公告)号：EP1590348A1
公开(公告)日：2005-11-02
申请号：EP03814164.4
申请日：2003-12-18
发明人： HAYS, David S., , NIWAS, Shri , KSHIRSAGAR, Tushar , GHOSH, Tarun K., , GUPTA, Shalley K., , HEPPNER, Philip D., , MERRILL, Bryon A., , BONK, Jason D., , DANIELSON, Michael E., , GERSTER, John F., , HARALDSON, Chad A., , JOHANNESSEN, Sarah C., , KAVANAGH, Maureen A., , LINDSTROM, Kyle J., , PRINCE, Ryan B., , RADMER, Matthew R., , RICE, Michael J., , SQUIRE, David J., , STRONG, Sarah A.,
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Aryl substituted imidazoquinoline compounds, according to formula I, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing w or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral., and neoplastic, are disclosed. formula (I): wherein: R is selected from the group consisting of alkyl, alkoxy, hydroxy, and trifluoromethyl;. N is 0 or 1; R3 is selected from the group consisting of: -Z-Ar,-Z-Ar’-Y-R4, -Z-Ar’-X-Y-R4, Z-Ar’-R5, and-Z-Ar'-X-R5; Ar is selected from the group consisting of aryl and heteroaryl both of which can be unsubstituted or can be substituted by one or more substituents independently selected from the group consisting of alkyl, alkenyl, alkoxy, methylenedioxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, carboxy, formyl, aryl, aryloxy, arylalkoxy, heteroaryl, heteroaryloxy, heteroarylalkoxy; heterocyctyl, heterocyclylalkyl, amino, alkylamino, and dialkylamino.
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7.发明公开
公开(公告)号：EP3902869A1
公开(公告)日：2021-11-03
申请号：EP19839148.4
申请日：2019-12-20
发明人： WHITING, Tien Yi T. H. , XIA, Ying , BOLTON, Justin M. , CHEN-HO, Kui , NIWAS, Shri , JANOSKI, Jonathan E. , SCHULTZ, Anthony F. , PATNODE, Gregg A. , THOMAS, Carla S. , FANSLER, Duane D.
IPC分类号： C08K5/375
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公开(公告)号：EP3701296A2
公开(公告)日：2020-09-02
申请号：EP18869548.0
申请日：2018-10-25
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公开(公告)号：EP3240682A1
公开(公告)日：2017-11-08
申请号：EP15876122.1
申请日：2015-12-28
CPC分类号： G02B5/128 , B32B7/12 , B32B15/082 , B32B2327/12 , B32B2333/12 , B32B2551/00 , G02B5/136
摘要： Retroreflective article and precursor articles formed during the preparation of the retroreflective articles are provided. Also, methods of making both the precursor articles and the retroreflective articles are provided. The retroreflective articles and the precursor articles contain a reflective layer that includes both a reflective metal and a polymeric blend. The polymeric blend includes both a fluorinated polymer and a (meth)acrylate polymer. The retroreflective articles typically have anti-staining properties, anti-corrosion properties, or both.
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公开(公告)号：EP3140684A1
公开(公告)日：2017-03-15
申请号：EP15724411.2
申请日：2015-04-30
发明人： NIWAS, Shri , MCCOY, Michael A. , XIA,Ying
IPC分类号： G02B5/128
摘要： Retroreflective articles include a layer of optical elements, the layer of optical elements being divided into at least a first segment (110) and second segment (120), and a bead bond layer (170) containing a colorant. The optical elements are partially embedded in the bead bond layer. The optical elements include transparent microspheres (140), a transparent polymeric layer (180), and at least one reflective layer. In the first segment of optical elements, the reflective layer is a dielectric reflective layer (150), and in the second segment of optical elements, the reflective layer is a reflective metallic layer (160). The retroreflective articles have improved wash durability.
摘要翻译： 逆反射制品包括一层光学元件，光学元件层被分成至少第一部分（110）和第二部分（120）以及包含着色剂的珠子接合层（170）。 光学元件部分地嵌入珠接合层中。 光学元件包括透明微球（140），透明聚合物层（180）和至少一个反射层。 在光学元件的第一段中，反射层是介电反射层（150），并且在光学元件的第二段中，反射层是反射金属层（160）。 回射制品具有改善的耐洗涤性。
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