公开(公告)号：EP2783216A4

公开(公告)日：2015-06-10

申请号：EP12852350

申请日：2012-11-20

申请人： ABAY SA

发明人： CUESICO CRISTINA ,  WALKER JEREMY ,  MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M

IPC分类号： G01N33/543 ,  G01N33/53 ,  G01N33/558 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/587 ,  G01N33/6854 ,  G01N33/6857 ,  G01N33/6893 ,  G01N2333/20 ,  G01N2333/29 ,  G01N2469/20

摘要： The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.

公开(公告)号：EP2773654A4

公开(公告)日：2015-04-29

申请号：EP12846033

申请日：2012-11-05

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNISM ,  WALKER JEREMY ,  CUESICO CRISTINA

IPC分类号： C07K14/00 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/56911 ,  C07K14/20 ,  G01N2333/20 ,  G01N2469/20

摘要： The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.