公开(公告)号：EP3096784A4

公开(公告)日：2017-12-06

申请号：EP15740392

申请日：2015-01-21

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M ,  ROGERS ANDREW P ,  FORSYTH TIMOTHY P ,  WALKER JEREMY D ,  CUESICO CRISTINA R

IPC分类号： A61K39/02 ,  A61K38/00 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： G01N33/6854 ,  C07K14/195 ,  G01N33/56911 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the Anaplasma Outer Membrane Protein proteins. The invention also provides devices, methods, and kits comprising the populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens and the diagnosis of anaplasmosis. Methods of identifying the particular Anaplasma species infecting a subject using the peptide populations of the invention are also disclosed.

公开(公告)号：EP3126835A4

公开(公告)日：2017-10-11

申请号：EP15772535

申请日：2015-04-03

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  WALKER JEREMY D ,  ARON KENNETH P ,  BLEILE DENNIS M ,  CUESICO CRISTINA R ,  FORSYTH TIMOTHY P

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/12 ,  A61K39/38 ,  C12Q1/04 ,  G01N33/569

CPC分类号： G01N33/56911 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides methods, kits, compositions, and devices useful for detection of antibodies that bind to Ehrlichia antigens and/or for differentiation of certain Ehrlichia species from others. In particular, the invention provides methods and kits useful for identifying species of Ehrlichia using populations of isolated peptides.

公开(公告)号：EP2906950A4

公开(公告)日：2016-05-25

申请号：EP13844762

申请日：2013-10-11

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M ,  FORSYTH TIMOTHY P ,  WALKER JEREMY D ,  CUESICO CRISTINA R

IPC分类号： G01N33/68 ,  C07K14/29 ,  C07K17/14 ,  G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54306 ,  C07K14/29 ,  C07K17/14 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/29 ,  G01N2469/20

摘要： The invention provides peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions and mixtures comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic and/or granulocytic ehrlichiosis.

公开(公告)号：EP1556688A4

公开(公告)日：2011-10-26

申请号：EP03809123

申请日：2003-10-17

申请人： ABAY SA

发明人： OSTOICH VLADIMIR E ,  ARON KENNETH ,  BLEILE DENNIS M

IPC分类号： G06F19/00 ,  C12Q1/00 ,  G01N31/00

CPC分类号： G16H10/40

摘要： Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteristics of a sample. These values are used in combination with reference data stored in a data module to generate a probability that the sample tested is a short sample, a long sample, or an acceptable sample. This probability and/or the status of the sample as a short sample, a long sample, or an acceptable sample are output to a user.

公开(公告)号：EP2783216A4

公开(公告)日：2015-06-10

申请号：EP12852350

申请日：2012-11-20

申请人： ABAY SA

发明人： CUESICO CRISTINA ,  WALKER JEREMY ,  MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M

IPC分类号： G01N33/543 ,  G01N33/53 ,  G01N33/558 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68

CPC分类号： G01N33/54393 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/587 ,  G01N33/6854 ,  G01N33/6857 ,  G01N33/6893 ,  G01N2333/20 ,  G01N2333/29 ,  G01N2469/20

摘要： The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.

公开(公告)号：EP2501718A4

公开(公告)日：2014-02-19

申请号：EP10832262

申请日：2010-11-19

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M

IPC分类号： C07K14/195 ,  C07K19/00 ,  G01N33/53

CPC分类号： G01N33/54306 ,  C07K14/195 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/56911 ,  G01N2333/29

公开(公告)号：EP2501719A4

公开(公告)日：2013-07-31

申请号：EP10832113

申请日：2010-11-17

申请人： ABAY SA

发明人： MEHRA RAJESH K ,  ARON KENNETH P ,  BLEILE DENNIS M

IPC分类号： C07K14/20 ,  C07K19/00 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6854 ,  G01N33/56911 ,  G01N2333/20

摘要： The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Borrelia antigens and the diagnosis of Lyme disease.