利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.009 秒)

    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES.
    2.
    发明公开
    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES. 失效
    BESTIMMUNG TRIZYKLISCHER ANTIDEPRESSIVA在GEGENWARTSTÖRENDERSUBSTANZEN。

    公开(公告)号：EP0619020A4

    公开(公告)日：1994-07-07

    申请号：EP92905134

    申请日：1991-12-13

    申请人： ABBOTT LAB

    发明人： ADAMCZYK MACIEJ ,  FISHPAUGH JEFFREY R ,  HARRINGTON CHARLES A ,  HARTTER DARYL E ,  HRUSKA ROBERT E

    IPC分类号： G01N30/06 ,  G01N30/88 ,  G01N30/91 ,  G01N33/542 ,  G01N33/94 ,  G01N33/50 ,  G01N30/02 ,  G01N30/22 ,  G01N33/53

    CPC分类号： G01N33/9466

    摘要： Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds. The selective modification results in the modified compound having a chemical structure which is substantially dissimilar to the chemical structure of the other one of said compounds wherein the compounds are substantially distinguishable from each other to permit the analytical determination of one or the other of such compounds by immunoassay, high pressure liquid chromatography, and thin layer chromatography techniques, especially for the fluorescent polarization immunoassay determination of tricyclic antidepressant drugs in the presence of phenothiazines.

    摘要翻译： 用于测定存在于测试样品中的感兴趣化合物的方法和试剂，所述测试样品还含有一种或多种干扰化合物，所述干扰化合物具有基本相似的化学结构，并且另外在分析上彼此不可区分，采用能够选择性地改变其中一种化学结构的预处理试剂 化合物没有显着改变或改变另一种化合物的化学结构。 选择性修饰导致修饰化合物具有与所述化合物中另一化合物的化学结构基本不相似的化学结构，其中所述化合物基本上彼此可区分以允许通过以下方式对这些化合物中的一种或另一种进行分析测定： 免疫测定法，高压液相色谱法和薄层色谱法技术，特别是用于吩噻嗪存在下的三环类抗抑郁药物的荧光偏振免疫测定法。