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公开(公告)号：EP1429796A2
公开(公告)日：2004-06-23
申请号：EP02731295.8
申请日：2002-04-10
申请人： ABBOTT LABORATORIES
发明人： HENKIN, Jack , HAVIV, Fortuna , BRADLEY, Michael, F. , DOUGLAS, Kalvin, M. , SCHNEIDER, Andrew, J.
摘要： The present invention discloses peptides which are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
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公开(公告)号：EP1450841A2
公开(公告)日：2004-09-01
申请号：EP02793859.6
申请日：2002-10-30
申请人： Abbott Laboratories
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0808 , C07K5/081 , C07K5/0815 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K5/1024
摘要： Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
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公开(公告)号：EP1450840A2
公开(公告)日：2004-09-01
申请号：EP02802499.0
申请日：2002-10-30
申请人： ABBOTT LABORATORIES
IPC分类号： A61K38/00
CPC分类号： C07K5/06043 , A61K38/00 , C07K5/06034 , C07K5/0606 , C07K5/06086 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/0823
摘要： Compounds having the formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
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公开(公告)号：EP1680415B1
公开(公告)日：2008-12-31
申请号：EP04785388.2
申请日：2004-10-08
申请人： ABBOTT LABORATORIES
IPC分类号： C07D401/06 , C07D403/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/08 , C07D491/10 , A61P35/00 , A61K31/435
CPC分类号： C07D401/14 , C07D401/06 , C07D403/06 , C07D405/14 , C07D409/14 , C07D471/08 , C07D491/10
摘要： Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
摘要翻译： 具有式（I）的化合物是血管生成抑制剂。 还公开了含有该化合物的组合物，制备该化合物的方法以及使用该化合物的治疗方法。
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5.发明公开AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY 审中-公开羰基SUBSTITUIRTE吡啶，PYRIDAZEN，嘧啶，吡嗪和三嗪类抗血管生成作用
公开(公告)号：EP1494672A1
公开(公告)日：2005-01-12
申请号：EP03719683.9
申请日：2003-04-03
申请人： Abbott Laboratories
发明人： HAVIV, Fortuna , BRADLEY, Michael, F. , HENKIN, Jack , DINGES, Jürgen , SAUER, Daryl, R. , KOLACZKOWSKI, Lawrence , VASUDEVAN, Anil , PARK, David, C.
IPC分类号： A61K31/455 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , C07D213/82 , C07D491/10 , C07D213/81 , C07D401/06 , C07D401/12 , C07D409/04 , C07D401/04 , C07D405/12 , C07D241/24 , C07D239/28
CPC分类号： C07D213/81 , A61K31/4439 , A61K31/4545 , A61K31/4747 , A61K31/496 , A61K31/541 , A61K31/551 , C07D213/82 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D491/10
摘要： Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds. A is selected from the group consisting of pyridine, pyridine N-oxide, pyridazine, pyrimidine. pyrazine, and triazine; R1 and R2, together with the nitrogen atom to which they are attached, form a five - to eight - membered ring containing an additional zero to two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; wherein the ring can be optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxyalkyl, alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, amino, aminocarbonyl, aryl, arylalkoxycarbonyl, wylalkyl, carboxy, formyl, haloalkyl, heterocycle, (heterocycle)alkyl, hydroxy, hydroxyalkoxyalkyl, hydroxyalkyl, and spiroheterocycle; R3 at each occurance is independently selected from the group consisting 'of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, alkylsulfanyl, amino, aminocarbonyl, aryl, arylalkyl, aryloxy, cyano, cyanoalkyl, cyanoalkyl, (cycloalkyl)alkyl, halo, haloalkyl, heterocycle, hydroxy, hydroxyalkyl, and nitro; X is selected from the group consisting of O, S, and CH2; and m is 0-4.
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6.发明公开
公开(公告)号：EP1451209A2
公开(公告)日：2004-09-01
申请号：EP02789322.1
申请日：2002-10-30
申请人： Abbott Laboratories
IPC分类号： C07K7/00
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1013
摘要： Compounds of formula (SEQ ID NO:2) and (SEQ ID NO:3), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
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公开(公告)号：EP1078002B1
公开(公告)日：2008-05-21
申请号：EP99927091.1
申请日：1999-05-21
申请人： ABBOTT LABORATORIES
发明人： HENKIN, Jack , HAVIV, Fortuna , BRADLEY, Michael, F. , KALVIN, Douglas, M. , SCHNEIDER, Andrew, J.
摘要： Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8 and A9 are amino acyl residues as defined herein.
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公开(公告)号：EP1680415A1
公开(公告)日：2006-07-19
申请号：EP04785388.2
申请日：2004-10-08
申请人： ABBOTT LABORATORIES
IPC分类号： C07D401/06 , C07D403/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/08 , C07D491/10 , A61P35/00 , A61K31/435
CPC分类号： C07D401/14 , C07D401/06 , C07D403/06 , C07D405/14 , C07D409/14 , C07D471/08 , C07D491/10
摘要： Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.
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9.发明公开
公开(公告)号：EP1451210A2
公开(公告)日：2004-09-01
申请号：EP02789330.4
申请日：2002-10-30
申请人： Abbott Laboratories
IPC分类号： C07K7/00
摘要： Compounds of formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.
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公开(公告)号：EP1078002A1
公开(公告)日：2001-02-28
申请号：EP99927091.1
申请日：1999-05-21
申请人： ABBOTT LABORATORIES
发明人： HENKIN, Jack , HAVIV, Fortuna , BRADLEY, Michael, F. , KALVIN, Douglas, M. , SCHNEIDER, Andrew, J.
摘要： Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8 and A9 are amino acyl residues as defined herein.
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