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    Delivery of highly lipophilic agents via medical devices
    3.
    发明公开
    Delivery of highly lipophilic agents via medical devices 有权
    VERABREICHUNG STARK LIPOPHILER WIRKSTOFFE MITTELS MEDISINISCHER VORRICHTUNGEN

    公开(公告)号：EP2327429A1

    公开(公告)日：2011-06-01

    申请号：EP10183267.3

    申请日：2006-03-22

    申请人： Abbott Laboratories

    发明人： Cromack, Keith R. ,  Toner, John L. ,  Burke, Sandra E. ,  Krasula, Richard W. ,  Schwartz, Lewis B.

    IPC分类号： A61L27/54

    CPC分类号： A61L31/10 ,  A61F2/04 ,  A61F2/82 ,  A61F2002/044 ,  A61F2002/047 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/606

    摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

    摘要翻译： 一种用于递送与医疗装置相关联的亲脂性试剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的 至少约5,000个，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至 课程。 此外，本发明涉及一种提高受试者通畅性的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

    Multiple drug delivery from a balloon and a prosthesis
    4.
    发明公开
    Multiple drug delivery from a balloon and a prosthesis 有权
    Abgabe mehrerer Arzneimittel aus einem Ballon und Prothese

    公开(公告)号：EP2301619A1

    公开(公告)日：2011-03-30

    申请号：EP10011851.2

    申请日：2005-03-17

    申请人： Abbott Laboratories

    发明人： Toner, John L. ,  Burke, Sandra E. ,  Cromack, Keith R. ,  Von Oepen, Randolf

    IPC分类号： A61M25/10 ,  A61F2/06 ,  A61L27/28 ,  A61L31/08

    CPC分类号： A61F2/91 ,  A61F2/86 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K47/6957 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00

    摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

    摘要翻译： 公开了用于从血管成形术球囊和诸如腔内支架的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从单独表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从分开的表面递送第一有益试剂和第二有益试剂的介入装置的方法。