-
1.发明公开REAGENTS AND METHODS FOR THE QUANTIFICATION OF AMITRIPTYLINE OR NORTRIPTYLINE IN BIOLOGICAL FLUIDS 失效试剂和生物体液或阿米替林去甲替林的定量测定方法。
公开(公告)号：EP0599935A1
公开(公告)日：1994-06-08
申请号：EP92917665.0
申请日：1992-07-29
申请人： ABBOTT LABORATORIES
CPC分类号： C07D223/28 , G01N33/533 , G01N33/9466 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Des réactifs et des méthodes d'immunoanalyse pour la quantification spécifique de l'amitriptyline ou de la nortriptyline dans un échantillon de test sont décrits et utilisent des anticorps préparés avec les dérivés de l'amitriptyline ou de la nortriptyline de formule (III) dans laquelle, pour l'amitriptyline, R représente CH3 et, pour la nortriptyline, R représente H. La présente invention décrit également la synthèse de traceurs de fluorescéine uniques ayant la structure de formule (IV) et de formule (V) dans lesquelles, pour une immunoanalyse d'amitriptyline spécifique, W1 représente un hétéroatome lié à l'anneau aromatique en position 2 ou en position 3, et pour une immunoanalyse de nortriptyline spécifique, W2 représente deux hétéroatomes liés ensemble et rattachés à l'anneau aromatique dans la position 2 ou dans la position 3, et dans lesquelles Q est une fraction détectable, de préférence la fluorescéine ou un dérivé de fluorescéine.
-
2.发明公开REAGENTS FOR MEASURING LEAD LEVELS VIA THE QUANTIFICATION OF PORPHOBILINOGEN 失效测量引线作者：THROUGH胆色素原数量化试剂
公开(公告)号：EP0876616A2
公开(公告)日：1998-11-11
申请号：EP96943648.0
申请日：1996-12-16
申请人： Abbott Laboratories
CPC分类号： C07D207/337 , C07D405/12 , G01N33/532 , G01N33/72 , G01N33/84
摘要： Immunoassay methods and reagents for measuring the levels of lead in a test sample via the quantification of porphobilinogen use antibodies prepared with compounds of Formulas (II) and (III), wherein X and Y are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to an immunogenic carrier material P wherein P is preferably bovine serum albumin. Also described are the synthesis of fluorescein tracers of the structure of Formulas (V) and (VII), wherein A and C are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to a detectable moiety Q, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.
-
3.发明授权
公开(公告)号：EP0619020B1
公开(公告)日：2000-11-08
申请号：EP92905134.0
申请日：1991-12-13
申请人： ABBOTT LABORATORIES
发明人： ADAMCZYK, Maciej , FISHPAUGH, Jeffrey, R. , HARRINGTON, Charles, A. , HARTTER, Daryl, E. , HRUSKA, Robert E.
CPC分类号： G01N33/9466
摘要： Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds. The selective modification results in the modified compound having a chemical structure which is substantially dissimilar to the chemical structure of the other one of said compounds wherein the compounds are substantially distinguishable from each other to permit the analytical determination of one or the other of such compounds by immunoassay, high pressure liquid chromatography, and thin layer chromatography techniques, especially for the fluorescent polarization immunoassay determination of tricyclic antidepressant drugs in the presence of phenothiazines.
-
4.发明授权REAGENTS AND METHODS FOR THE QUANTIFICATION OF AMITRIPTYLINE OR NORTRIPTYLINE IN BIOLOGICAL FLUIDS 失效试剂和方法在生物流体或阿米替林去甲替林的定量测定
公开(公告)号：EP0599935B1
公开(公告)日：2000-09-13
申请号：EP92917665.9
申请日：1992-07-29
申请人： ABBOTT LABORATORIES
IPC分类号： G01N33/533 , G01N33/94 , C07D311/82 , C07D493/10 , C07K16/44
CPC分类号： C07D223/28 , G01N33/533 , G01N33/9466 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of formula (III), wherein for amitriptyline, R is CH3, and for nortriptyline, R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of formula (IV) and formula (V), wherein for a specific amitriptyline immunoassay, W1 is a heteroatom linked to the aromatic ring at the 2 or 3 position, and for a specific nortriptyline immunoassay, W2 is two heteroatoms linked together and attached to the aromatic ring at the 2 or 3 position, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.
-
5.发明授权REAGENTS AND METHODS FOR THE QUANTIFICATION OF TOTAL DOXEPINS IN BIOLOGICAL FLUIDS 失效为了定量总含量的试剂和方法DOXEPINEN生物体液
公开(公告)号：EP0641440B1
公开(公告)日：2000-11-08
申请号：EP92917171.8
申请日：1992-07-29
申请人： ABBOTT LABORATORIES
IPC分类号： G01N33/94 , C07D313/12 , G01N33/533 , C07K16/44
CPC分类号： C07D313/12 , G01N33/533 , G01N33/9466 , Y10S436/815
摘要： Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of formula (II), wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3 and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of formula (II), and the labeled reagent is also prepared from the doxepin derivative of formula (II).
-
6.发明公开REAGENTS AND METHODS FOR THE QUANTIFICATION OF TOTAL DOXEPINS IN BIOLOGICAL FLUIDS 失效为了定量总含量的试剂和方法DOXEPINEN生物体液。
公开(公告)号：EP0641440A1
公开(公告)日：1995-03-08
申请号：EP92917171.0
申请日：1992-07-29
申请人： ABBOTT LABORATORIES
CPC分类号： C07D313/12 , G01N33/533 , G01N33/9466 , Y10S436/815
摘要： Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of formula (II), wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3 and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of formula (II), and the labeled reagent is also prepared from the doxepin derivative of formula (II).
-
7.发明公开
公开(公告)号：EP0619020A1
公开(公告)日：1994-10-12
申请号：EP92905134.0
申请日：1991-12-13
申请人： ABBOTT LABORATORIES
发明人： ADAMCZYK, Maciej , FISHPAUGH, Jeffrey, R. , HARRINGTON, Charles, A. , HARTTER, Daryl, E. , Hruska, Robert E.
CPC分类号： G01N33/9466
摘要： Procédé et réactifs de détection d'un composé présent dans un échantillon d'essai contenant également un ou plusieurs composés d'interférence possédant des structures sensiblement similaires, et impossibles à différencier analytiquement par un autre procédé. Ce procédé utilise un réactif de traitement préliminaire capable de modifier de manière sélective la structure chimique de l'un des composés sans modifier ou changer de façon significative la structure chimique de l'un des autres composés. La modification sélective résulte en un composé modifié possédant une structure chimique qui est sensiblement dissemblable à la structure chimique de l'un des autres composés, dans laquelle les composés se distinguent sensiblement les uns des autres pour permettre la détermination analytique de l'un ou de l'autre composé en faisant appel aux techniques d'immunodosage, de chromatographie liquide sous pression élévée et à la chromatographie en couche mince, notamment pour la détermination par immunodosage de polarisation fluorescente de médicaments antidépresseurs tricycliques en présence de phénothiazines.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.011 秒)
