公开(公告)号：EP2117526A2

公开(公告)日：2009-11-18

申请号：EP07854765.0

申请日：2007-11-26

申请人： Abbott Laboratories

发明人： SOUERS, Andrew J. ,  GAO, Ju ,  HANSEN, Todd Matthew ,  IYENGAR, Rajesh R. ,  KYM, Philip R. ,  LIU, Bo X ,  PEI, Zhonghua ,  YEH, Vince ,  ZHAO, Gang ,  XIN, Zhili

IPC分类号： A61K31/17 ,  C07C229/40 ,  A61P1/16 ,  A61P3/00

CPC分类号： C07D487/04 ,  C07C59/54 ,  C07C275/42 ,  C07D211/60 ,  C07D231/12 ,  C07D231/20 ,  C07D249/08 ,  C07D263/48 ,  C07D277/40 ,  C07D401/04 ,  C07D407/12 ,  C07D407/14 ,  C07D413/12 ,  C07D413/14

摘要： Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.

公开(公告)号：EP1534703A2

公开(公告)日：2005-06-01

申请号：EP03760268.7

申请日：2003-06-11

申请人： ABBOTT LABORATORIES

发明人： BLACKBURN, Christopher ,  LAI, Su-jen ,  LEE, Jennifer, G. ,  MAGUIRE, Martin ,  PATANE, Michael, A. ,  LAMARCHE, Matthew, J. ,  CULLIS, Courtney, A. ,  BROWN, James ,  VASUDEVAN, Anil ,  FREEMAN, Jennifer, C. ,  MULHERN, Mathew, M. ,  LYNCH, John, K. ,  GAO, Ju ,  WODKA, Dariusz ,  SOUERS, Andrew, J. ,  IYENGAR, Rajesh

IPC分类号： C07D405/00

CPC分类号： C07D405/14 ,  C07D401/14 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14

摘要： This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R )-, R , R , R , R , R , R , and Ring A are defined in the specification. Coumarin and quinolone compounds where R and R together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

公开(公告)号：EP2117526B1

公开(公告)日：2013-04-03

申请号：EP07854765.0

申请日：2007-11-26

申请人： Abbott Laboratories

发明人： SOUERS, Andrew J. ,  GAO, Ju ,  HANSEN, Todd Matthew ,  IYENGAR, Rajesh R. ,  KYM, Philip R. ,  LIU, Bo X ,  PEI, Zhonghua ,  YEH, Vince ,  ZHAO, Gang ,  XIN, Zhili

IPC分类号： A61K31/17 ,  C07C229/40 ,  A61P1/16 ,  A61P3/00 ,  C07D231/20 ,  C07D263/48 ,  C07D277/38 ,  C07D403/04 ,  C07D487/04 ,  C07D405/04

CPC分类号： C07D487/04 ,  C07C59/54 ,  C07C275/42 ,  C07D211/60 ,  C07D231/12 ,  C07D231/20 ,  C07D249/08 ,  C07D263/48 ,  C07D277/40 ,  C07D401/04 ,  C07D407/12 ,  C07D407/14 ,  C07D413/12 ,  C07D413/14