公开(公告)号：EP0475206A3

公开(公告)日：1992-08-05

申请号：EP91114542.3

申请日：1991-08-29

申请人： ABBOTT LABORATORIES

发明人： Winn, Martin ,  De, Biswanath ,  Zydowsky, Thomas M. ,  Kerkman, Daniel J. ,  De Bernardis, John F. ,  Rosenberg, Saul H. ,  Shiosaki, Kazumi ,  Basha, Fatima Z. ,  Tasker, Andrew S. ,  Von Geldern, Thomas W. ,  Kester, Jeffrey A. ,  Holleman, William H.

IPC分类号： C07D403/12 ,  A61K31/44 ,  C07D401/12 ,  C07D239/42 ,  C07D257/04 ,  C07D405/14 ,  A61K31/495

CPC分类号： C07D239/42 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

摘要： Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I).
The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.

公开(公告)号：EP0475206A2

公开(公告)日：1992-03-18

申请号：EP91114542.3

申请日：1991-08-29

申请人： ABBOTT LABORATORIES

发明人： Winn, Martin ,  De, Biswanath ,  Zydowsky, Thomas M. ,  Kerkman, Daniel J. ,  De Bernardis, John F. ,  Rosenberg, Saul H. ,  Shiosaki, Kazumi ,  Basha, Fatima Z. ,  Tasker, Andrew S. ,  Von Geldern, Thomas W. ,  Kester, Jeffrey A. ,  Holleman, William H.

IPC分类号： C07D403/12 ,  A61K31/44 ,  C07D401/12 ,  C07D239/42 ,  C07D257/04 ,  C07D405/14 ,  A61K31/495

CPC分类号： C07D239/42 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

摘要： Novel pyrimidine, pyridine, pyridazine, pyrazine and triazine compounds are provided of the formula (I).

The compounds of the invention are useful for treating hypertension, edema, renal failure, congestive heart failure, psoriasis and glaucoma, and in the prevention and treatment of atherosclerosis or to treat gastrointestinal disorders associated with enhanced contractility and/or motility of intestinal smooth muscle or to treat contractile disorders of the uterus.

摘要翻译： 由式（I）提供新的嘧啶，吡啶，哒嗪，吡嗪和三嗪化合物。 本发明的化合物可用于治疗高血压，水肿，肾衰竭，充血性心力衰竭，牛皮癣和青光眼，以及预防和治疗动脉粥样硬化或治疗与增强的肠收缩力和/或运动性相关的胃肠道疾病 平滑肌或治疗子宫收缩性疾病。