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    Tetrahydro-benzo(e) isoindolines
    1.
    发明公开
    Tetrahydro-benzo(e) isoindolines 失效
    四氢 - 苯并（e）异二氢吲哚。

    公开(公告)号：EP0095666A2

    公开(公告)日：1983-12-07

    申请号：EP83104932.5

    申请日：1983-05-19

    申请人： ABBOTT LABORATORIES

    发明人： DeBernardis, John Francis ,  Kerkman, Daniel Joseph ,  McClellan, William John

    IPC分类号： C07D209/62 ,  C07D405/06 ,  C07D209/66 ,  C07C121/48 ,  A61K31/40 ,  C07C121/75

    CPC分类号： C07D405/06 ,  C07C255/00 ,  C07D209/62 ,  C07D209/66

    摘要： DisGosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula
    wherein R, R,, and R 2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or
    wherein R. and R 5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula
    wherein R 6 is loweralkyl of 1 to 4 carbon atoms; or R and R,, or R, and R 2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R, or R 2 must be other than hydrogen; and R 3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula
    wherein m is 0, 1 or 2, p is 0 or 1, R 7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R 8 and R 9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1. to 4 carbon atoms, or halo, or R, and R 9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan.

    摘要翻译： 本文公开的是可用于治疗高血压的四氢 - 苯并[e]异吲哚啉，其由式CHEM表示，其中R，R 1和R 2独立地选自氢，羟基，1至3个碳原子的低级烷氧基，低级链烯氧基 1至3个碳原子的苄基氧基，苯甲酰氧基，硫代甲基，卤素或CHEM，其中R 4和R 5独立地选自氢，1至4个碳原子的低级酰基或式CHEM的磺酰基，其中R 6是1的低级烷基 至4个碳原子; 或R和R 1，或R 1和R 2可以一起形成亚甲二氧基或亚乙二氧基桥; 条件是R，R 1或R 2中的至少一个必须不是氢; 并且R 3是氢; 1至4个碳原子的低级烷基; 1至4个碳原子的卤素取代的低级烷基; 其中m为0,1或2，p为0或1，R 7为氢或1至4个碳原子的低级烷基，R 8和R 9独立地选自氢，羟基，甲氧基，低级烷基1 至4个碳原子，或卤素，或R8和R9可以一起形成甲基二氧基或亚乙二氧基桥; 或1,4-苯并二恶烷。

    Tetrahydro-benzo(e) isoindolines
    2.
    发明公开
    Tetrahydro-benzo(e) isoindolines 失效
    四氢 - 苯并（e）异吲哚啉

    公开(公告)号：EP0095666A3

    公开(公告)日：1985-01-16

    申请号：EP83104932

    申请日：1983-05-19

    申请人： ABBOTT LABORATORIES

    发明人： DeBernardis, John Francis ,  Kerkman, Daniel Joseph ,  McClellan, William John

    IPC分类号： C07D209/62 ,  C07D405/06 ,  C07D209/66 ,  C07C121/48 ,  A61K31/40 ,  C07C121/75

    CPC分类号： C07D405/06 ,  C07C255/00 ,  C07D209/62 ,  C07D209/66

    摘要： DisGosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula
    wherein R, R,, and R 2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or
    wherein R. and R 5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula
    wherein R 6 is loweralkyl of 1 to 4 carbon atoms; or R and R,, or R, and R 2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R, or R 2 must be other than hydrogen; and R 3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula
    wherein m is 0, 1 or 2, p is 0 or 1, R 7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R 8 and R 9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1. to 4 carbon atoms, or halo, or R, and R 9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan.

    摘要翻译： 本发明公开了用于治疗高血压的四氢 - 苯并[e]异吲哚啉，其由下式表示：其中R 1，R 2和R 2独立地选自氢，羟基，1至3个碳原子的低级烷氧基，1的低级链烯氧基 苄氧基，苯甲酰氧基，硫代甲基，卤素，或者其中R和R 5独立地选自氢，1-4个碳原子的低级π-酰氨基或下式的磺酰基：其中R 6为1-4个碳原子的低级烷基; 或R 1和R 2或R 1和R 2可一起形成亚甲二氧基或亚乙二氧基桥; 条件是R 1，R 2或R 2中的至少一个必须不是氢; 和R3是氢; 具有1至4个碳原子的低级烷基; 卤素取代的1至4个碳原子的低级烷基; 其中m为0,1或2，p为0或1，R 7为氢或1-4个碳原子的低级烷基，R 8和R 9独立地选自氢，羟基，甲氧基，1-4低级烷基 碳原子或卤素，或R 1和R 9可一起形成亚甲基二氧基或亚乙基二氧桥; 或1,4-苯并二恶烷。