公开(公告)号：EP2258415A3

公开(公告)日：2011-03-23

申请号：EP10181379.8

申请日：2002-09-10

申请人： Abbott Laboratories

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

摘要： A medical device comprising a supporting structure having a coating on the surface thereof, the coating containing a therapeutic substance, such as, for example, a drug. Supporting structures for the medical devices that arc suitable for use in this invention include, but arc not limited to, coronary stcnts, peripheral stcnts, catheters, arteriovenous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,

公开(公告)号：EP2277570A2

公开(公告)日：2011-01-26

申请号：EP10012123.5

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure and the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one inflammatory agent.

摘要翻译： 包含支持结构和治疗性物质或其药学上可接受的盐或前药以及至少一种炎性介质的医疗装置。

公开(公告)号：EP2292280A1

公开(公告)日：2011-03-09

申请号：EP10012124.3

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure and the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one other therapeutic substance selected from anti-platelet agents, anti-thrombotic agents and thrombolytic agents.

摘要翻译： 包含支持结构和治疗性物质或其药学上可接受的盐或前药以及至少一种选自抗血小板剂，抗血栓形成剂和血栓溶解剂的其他治疗性物质的医疗装置。

公开(公告)号：EP2258415A2

公开(公告)日：2010-12-08

申请号：EP10181379.8

申请日：2002-09-10

申请人： Abbott Laboratories

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

摘要： A medical device comprising a supporting structure having a coating on the surface thereof, the coating containing a therapeutic substance, such as, for example, a drug. Supporting structures for the medical devices that arc suitable for use in this invention include, but arc not limited to, coronary stcnts, peripheral stcnts, catheters, arteriovenous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to,

摘要翻译： 一种医疗装置，包括在其表面具有涂层的支撑结构，所述涂层含有治疗物质，例如药物。 适合用于本发明的医疗器械的支撑结构包括但不限于冠状动脉狭窄，外周静脉，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于，

公开(公告)号：EP2277569A3

公开(公告)日：2011-03-09

申请号：EP10012122.7

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure and the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one agent that inhibits cytokine and chemokine binding.

摘要翻译： 包含支持结构和治疗物质或其药学上可接受的盐或前药以及至少一种抑制细胞因子和趋化因子结合的药剂的医疗装置。

公开(公告)号：EP2277566A3

公开(公告)日：2011-03-02

申请号：EP10012119.3

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure and the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one matrix metalloproteinase inhibitor.

摘要翻译： 包含支持结构和治疗性物质或其药学上可接受的盐或前药以及至少一种基质金属蛋白酶抑制剂的医疗装置。

公开(公告)号：EP2277566A2

公开(公告)日：2011-01-26

申请号：EP10012119.3

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure and the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one matrix metalloproteinase inhibitor.

摘要翻译： 包含支持结构和治疗物质或其药学上可接受的盐或前药以及至少一种基质金属蛋白酶抑制剂的医疗器械。

公开(公告)号：EP2277565A2

公开(公告)日：2011-01-26

申请号：EP10012118.5

申请日：2005-10-28

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L29/16 ,  A61K31/7048 ,  A61P9/10

CPC分类号： A61K31/7048 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  C07D498/18

摘要： A medical device comprising a support structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, said carrier or excipient containing the therapeutic substance

or a pharmaceutically acceptable salt or prodrug thereof and at least one other therapeutic substance selected from the group consisting of anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, thrombolytic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, and cytostatic drugs.

摘要翻译： 一种医疗装置，其包含能够容纳或承载药学上可接受的载体或赋形剂的载体结构，所述载体或赋形剂含有治疗性物质或其药学上可接受的盐或前药以及至少一种选自下列的其它治疗性物质： 增殖剂，抗血小板剂，抗炎剂，抗血栓剂，血栓溶解剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗血液流变剂，基质金属蛋白酶抑制剂和细胞抑制药 。

公开(公告)号：EP2258415B1

公开(公告)日：2014-10-15

申请号：EP10181379.8

申请日：2002-09-10

申请人： ABBOTT LABORATORIES

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/606 ,  C07D498/18

公开(公告)号：EP2255836A3

公开(公告)日：2011-04-06

申请号：EP10166508.1

申请日：2002-09-10

申请人： Abbott Laboratories

发明人： Mollison, Karl, W. ,  Lecaptain, Angela, M. ,  Burke, Sandra, E. ,  Cromack, Keith, R. ,  Tarcha, Peter, J. ,  Chen, Yen-Chih, J. ,  Toner, John, L.

IPC分类号： A61L31/16 ,  A61L27/54

CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I), This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, antiinflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.