公开(公告)号：EP1744162A4

公开(公告)日：2007-07-11

申请号：EP05728904

申请日：2005-03-31

申请人： ABURATANI HIROYUKI ,  PERSEUS PROTEOMICS INC ,  CHUGAI PHARMACEUTICAL CO LTD

发明人： ABURATANI HIROYUKI ,  HIPPO YOSHITAKA ,  WATANABE AKIRA ,  FUKAYAMA MASASHI ,  ITO YUKIO ,  ARAI MASAHIRO ,  ITO HIROTAKA ,  OHTOMO TOSHIHIKO ,  FUNAHASHI SHIN-ICHI ,  KINOSHITA YASUKO

IPC分类号： G01N33/574 ,  C07K16/30 ,  C12N15/02 ,  C12N15/09 ,  G01N33/576

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/57438 ,  G01N33/57488 ,  G01N33/576

摘要： A method of cancer diagnosis characterized in that ROBO1 protein is detected. Further, there is disclosed a method of treating diseases attributed to abnormal cell growth, comprising administering an antibody capable of binding to ROBO1, and are disclosed, comprising an antibody capable of binding to ROBO1 as an active ingredient, a pharmaceutical composition, cytostatic agent and anticancer agent. Still further, there is disclosed a method of inhibiting the growth of ROBO1 expression cells or method of inducing cytotoxicity in ROBO1 expression cells, comprising bringing an antibody capable of binding to ROBO1 into contact with ROBO1 expression cells. Moreover, there is disclosed a method of monitoring the intensification of hepatitis severity, comprising detection of ROBO1 protein.

摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 此外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露。 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROB01蛋白来监测肝炎进展的方法。