公开(公告)号：EP0639276A4

公开(公告)日：1995-09-20

申请号：EP93910996

申请日：1993-04-28

申请人： AFFYMAX TECH NV

发明人： FODOR STEPHEN P A ,  STRYER LUBERT

IPC分类号： C07K1/04 ,  C07K1/06 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/68 ,  C07K17/00 ,  C12Q1/70 ,  G01N33/543

CPC分类号： C40B30/04 ,  B01J2219/00585 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00707 ,  C07K1/047 ,  C07K1/06 ,  C12Q1/6811 ,  C12Q1/6874 ,  G01N33/6845

摘要： A method and library for determining the sequence of monomers in a polymer which is complementary to a receptor. The method provides for formation of pooled (6) and separate (10, 12) products. Separate products are subjected only to subsequent pooled coupling steps. Each pooled product is subsequently divided for formation of pooled and separate products. The resulting polymer library includes groups of polymer products. A first group of products (42) is used to identify the monomer at a first location in a polymer that is complementary to a receptor. A second group of products (44) is used to identify the monomer at a second location in a polymer that is complementary to a receptor.