公开(公告)号：EP0842293A4

公开(公告)日：2001-03-21

申请号：EP96923256

申请日：1996-06-07

申请人： AFFYMAX TECH NV

发明人： SCHATZ PETER J ,  CULL MILLARD G ,  MILLER JEFF F ,  STEMMER WILLEM P C ,  GATES CHRISTIAN M

IPC分类号： C12N1/21 ,  C12N15/10 ,  C12Q1/68 ,  C12N15/62 ,  C12N15/70 ,  G01N33/68

CPC分类号： C12N15/1075 ,  C12Q1/6811

摘要： A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA binding protein can be used to screen for novel ligands. The screening method results in the formation of a complex comprising the fusion protein bound to a receptor through the random peptide ligand and to the recombinant DNA vector through the DNA binding protein.

公开(公告)号：EP0752008A4

公开(公告)日：1999-03-17

申请号：EP95911826

申请日：1995-02-17

申请人： AFFYMAX TECH NV

发明人： STEMMER WILLEM P C ,  CRAMERI ANDREAS

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  C07K14/435 ,  C07K14/545 ,  C07K16/00 ,  C12N9/38 ,  C12N9/86 ,  C12N15/00 ,  C12N15/10 ,  C12P21/08 ,  C12Q1/68 ,  C40B40/02 ,  G01N33/53 ,  G01N33/566

CPC分类号： C40B40/02 ,  C07K14/43595 ,  C07K14/545 ,  C07K16/00 ,  C07K2317/565 ,  C07K2317/622 ,  C12N9/2471 ,  C12N9/86 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12Q1/68 ,  C12Q1/6811 ,  C12Y302/01023 ,  C12Y305/02006 ,  C40B40/08 ,  C40B50/06

公开(公告)号：EP0886648A1

公开(公告)日：1998-12-30

申请号：EP96919296

申请日：1996-06-07

申请人： JOHNSON & JOHNSON CORP ,  AFFYMAX TECH NV

发明人： WRIGHTON NICHOLAS C ,  DOWER WILLIAM J ,  CHANG RAY S ,  KASHYAP ARUN K ,  JOLLIFFE LINDA K ,  JOHNSON DANA ,  MULCAHY LINDA

IPC分类号： A61K38/22 ,  A61K38/00 ,  A61P7/06 ,  C07K7/08 ,  C07K14/505 ,  C07K7/00 ,  A61K38/03 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  C07K7/06 ,  C07K7/64 ,  C07K9/00 ,  C07K14/00

CPC分类号： C07K14/505 ,  A61K38/00

摘要： Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3X4X5GPX6TWX7X8 (SEQ ID NO:) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X5 is M, F, or I; X6 is independently selected from any one of the 20 genetically coded L-amino acids; X7 is D, E, I, L, or V; and X8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.

公开(公告)号：EP0647133A4

公开(公告)日：1997-10-29

申请号：EP93915319

申请日：1993-06-11

申请人： AFFYMAX TECH NV

发明人： HALE RON L ,  LU AMY ,  SOLAS DENNIS ,  SELICK HAROLD E ,  OLDENBURG KEVIN R ,  ZAFFARONI ALEJANDRO C

IPC分类号： A61K9/00 ,  A61K47/48 ,  A61K9/70

CPC分类号： A61K31/568 ,  A61K9/0009 ,  A61K47/541 ,  A61K47/6957 ,  B82Y5/00

公开(公告)号：EP0659188A4

公开(公告)日：1995-11-22

申请号：EP93922176

申请日：1993-09-10

申请人： AFFYMAX TECH NV

发明人： CAMPBELL DAVID A ,  JACOBS JEFFREY W

IPC分类号： C07F9/40 ,  C07K5/06

CPC分类号： C07K5/06191 ,  C07F9/40

摘要： Phosphonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relatively insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.

公开(公告)号：EP0562047A4

公开(公告)日：1995-11-02

申请号：EP92904971

申请日：1991-12-06

申请人： AFFYMAX TECH NV

发明人： FODOR STEPHEN P A ,  SOLAS DENNIS W ,  DOWER WILLIAM J

IPC分类号： B01J19/00 ,  C07B61/00 ,  C07H19/10 ,  C07H21/00 ,  C07K1/04 ,  C07K17/06 ,  C07K17/14 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N15/14 ,  G03F7/00 ,  G03F7/26 ,  G03F7/38 ,  G11C13/02 ,  C07H15/12 ,  G01N33/48 ,  G01N33/566

CPC分类号： G03F7/00 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00432 ,  B01J2219/00434 ,  B01J2219/00436 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00531 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y10/00 ,  B82Y30/00 ,  C07B2200/11 ,  C07H19/10 ,  C07H21/00 ,  C07K1/042 ,  C07K1/045 ,  C07K17/06 ,  C07K17/14 ,  C12Q1/6804 ,  C12Q1/6809 ,  C12Q1/6816 ,  C12Q1/6827 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q1/6874 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N15/1475 ,  G03F7/265 ,  G03F7/38 ,  G11C13/0014 ,  G11C13/0019 ,  C12Q2565/513 ,  C12Q2565/507 ,  C12Q2545/101 ,  C12Q2525/185 ,  C12Q2565/514 ,  C12Q2563/173 ,  C12Q2563/119 ,  C12Q2563/149 ,  C12Q2525/151 ,  C12Q2525/179 ,  C12Q2525/204

摘要： The present invention provides methods and appartus for sequencing, fingerprinting and mapping biological polymers, particularly polynucleotides. The methods make use of a plurality of positionally distinct sequence specific recognition reagents, such as polynucleotides. The apparatus employs a substrate comprising positionally distinct sequence specific recognition reagents, such as polynucleotides, which are preferably localized at high densities. The methods and apparatus of the present invention can be used for determining the sequence of polynucleotides, mapping polynucleotides, and developing polynucleotide fingerprints. Polynucleotide fingerprints can be used for identifying individuals, tissue samples, pathological conditions, genetic diseases, infectious diseases, and other applications. Polynucleotide fingerprints can also be used for classification of bioligical samples, including taxonomy, and to characterize their sources. The invention also provides polynucleotide mapping, fingerprinting, and sequencing as valuable laboratory research tools for use in biological investigations.

公开(公告)号：EP0639276A4

公开(公告)日：1995-09-20

申请号：EP93910996

申请日：1993-04-28

申请人： AFFYMAX TECH NV

发明人： FODOR STEPHEN P A ,  STRYER LUBERT

IPC分类号： C07K1/04 ,  C07K1/06 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/68 ,  C07K17/00 ,  C12Q1/70 ,  G01N33/543

CPC分类号： C40B30/04 ,  B01J2219/00585 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00707 ,  C07K1/047 ,  C07K1/06 ,  C12Q1/6811 ,  C12Q1/6874 ,  G01N33/6845

摘要： A method and library for determining the sequence of monomers in a polymer which is complementary to a receptor. The method provides for formation of pooled (6) and separate (10, 12) products. Separate products are subjected only to subsequent pooled coupling steps. Each pooled product is subsequently divided for formation of pooled and separate products. The resulting polymer library includes groups of polymer products. A first group of products (42) is used to identify the monomer at a first location in a polymer that is complementary to a receptor. A second group of products (44) is used to identify the monomer at a second location in a polymer that is complementary to a receptor.

公开(公告)号：EP0832100A4

公开(公告)日：1998-09-02

申请号：EP96921482

申请日：1996-06-06

申请人： AFFYMAX TECH NV

发明人： CAMPBELL DAVID A ,  PATEL DINESH V ,  XIAO XIAO Y

IPC分类号： C07C323/60 ,  C07K5/06 ,  C07K5/072 ,  C07K5/00

CPC分类号： C07C323/60 ,  C07C2601/14 ,  C07K5/06043 ,  C07K5/06095

公开(公告)号：EP0604552A4

公开(公告)日：1993-08-02

申请号：EP92920422

申请日：1992-09-16

申请人： AFFYMAX TECH NV

发明人： DOWER WILLIAM J ,  BARRETT RONALD W ,  GALLOP MARK A ,  NEEDELS MICHAEL C

IPC分类号： C12N15/09 ,  B01J19/00 ,  C07B61/00 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C07K1/04 ,  C07K1/06 ,  C07K5/00 ,  C07K7/00 ,  C08F8/00 ,  C08G85/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  C07K5/10 ,  C07K7/06 ,  C12N15/10 ,  C12N15/11

CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00306 ,  B01J2219/00313 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00565 ,  B01J2219/00572 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  C07B2200/11 ,  C07H19/10 ,  C07H19/14 ,  C07H21/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  Y10S435/81 ,  Y10T436/143333

摘要： A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.

公开(公告)号：EP0730663A4

公开(公告)日：2000-02-23

申请号：EP95900441

申请日：1994-10-26

申请人： AFFYMAX TECH NV

发明人： CHEE MARK ,  CRONIN MAUREEN T ,  FODOR STEPHEN P A ,  GINGERAS THOMAS R ,  HUANG XIAOHUA C ,  HUBBELL EARL A ,  LIPSHUTZ ROBERT J ,  LOBBAN PETER E ,  MIYADA CHARLES GARRETT ,  MORRIS MACDONALD S ,  SHAH NILA ,  SHELDON EDWARD L

IPC分类号： C12N15/09 ,  C07B61/00 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N33/53 ,  G01N37/00 ,  C07H21/02

CPC分类号： B82Y30/00 ,  B01J2219/00432 ,  B01J2219/00529 ,  B01J2219/00608 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  C07B2200/11 ,  C07H21/00 ,  C12Q1/6837 ,  C12Q1/6874 ,  C40B40/06 ,  C40B60/14 ,  C12Q2525/197 ,  C12Q2525/161

摘要： The invention provides chips of immobilized probes, and methods employing the chips, for comparing a reference polynucleotide sequence of known sequence with a target sequence showing substantial similarity with the reference sequence, but differing in the presence of e.g., mutations.

摘要翻译： 本发明提供了固定化探针的芯片和使用该芯片的方法，用于将已知序列的参考多核苷酸序列与显示与参考序列基本相似但在例如突变存在方面不同的靶序列进行比较。