公开(公告)号：EP3456710A1

公开(公告)日：2019-03-20

申请号：EP17796123.2

申请日：2017-05-09

申请人： AGC INC. ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： YASUDA, Arata ,  MATSUMURA, Yasushi ,  SAWADA, Kazuyoshi ,  NANBA, Hiroyoshi ,  TAGUCHI, Kazuki

IPC分类号： C07C405/00 ,  A61K31/5575 ,  A61K47/40 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00

摘要： The present invention relates to a novel prostaglandin derivative having an alkynyl group on ω-chain, particularly, a novel prostaglandin derivative having a double bond at the 2-position and an alkynyl group on the ω-chain and a medicament containing the compound as an active ingredient.
According to the present invention, a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof;

wherein each symbol is as defined in the present specification, or a cyclodextrin clathrate compound thereof, and a medicament containing the compound as an active ingredient, particularly, a medicament for the prophylaxis or treatment of a blood flow disorder associated with spinal canal stenosis or chronic arterial occlusion, can be provided.

公开(公告)号：EP3434665A1

公开(公告)日：2019-01-30

申请号：EP17769802.4

申请日：2017-02-24

申请人： AGC INC.

发明人： AKIYA, Takashi ,  KASAGAWA, Mitsugu ,  ICHINOKAWA, Naoki ,  ONOZAKI, Yu ,  KAWAGUCHI, Satoshi ,  TOMIYORI, Yusuke ,  YASUDA, Arata

IPC分类号： C07C67/00 ,  C07C43/313 ,  C07C67/62 ,  C07C69/653

摘要： The present invention provides a production method of α-fluoroacrylate ester, a composition containing a highly-pure fluorocyclopropane derivative and a composition containing highly-pure α-fluoroacrylate ester. The present invention relates to a method of producing a compound represented by the following formula (F), including subjecting a composition containing a compound represented by the following formula (A) to a purification treatment in the order of distillation and washing with an aqueous alkali solution to give a purified product containing a compound represented by the following formula (A), and subjecting the purified product to a thermal decomposition reaction, a composition containing a highly-pure compound represented by the following formula (A), and a composition containing a highly-pure compound represented by the following formula (F), wherein R may be the same or different and is a monovalent hydrocarbon group, and X is a halogen atom: