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    Process for producing a lymphokine
    1.
    发明公开
    Process for producing a lymphokine 失效
    生产LYMPHOKINE的方法

    公开(公告)号：EP0077571A3

    公开(公告)日：1983-10-12

    申请号：EP82109658

    申请日：1982-10-19

    申请人： AJINOMOTO CO., INC. ,  Hamaoka, Toshiyuki

    发明人： Hamaoka, Toshiyuki ,  Takatsu, Kiyoshi ,  Yoshimoto, Ryota ,  Hamuro, Junji

    IPC分类号： C12F01/00 ,  C12N15/00 ,  C12P21/00 ,  C12R01/91 ,  C12N05/00

    CPC分类号： C12N5/163 ,  C07K14/53 ,  C07K14/55 ,  C07K14/57

    摘要： A lymphokine in purified form or in the form of a lymphokine containing culture supernatant may be obtained by collecting lymphocytes from an animal or a human sensitized by an immunogen which induces the production of an antibody, selectively concentrating the lymphokine producing cells, forming a fused cell hybrid between the lymphokine producing cells and animal derived tumor cells, cloning the obtained hybrid, selecting the clone which spontaneously produces the lymphokine, culturing the clone to produce the lymphokine, and optionally recovering the lymphokine from the culture and purifying the lymphokine. This process is especially effective for producing interleukin 2, colony stimulating factor, T cells replacing factor, macrophage activating factor or immune interferon.

    Process for producing a lymphokine
    4.
    发明公开
    Process for producing a lymphokine 失效
    Verfahren zur Herstellung einer Lymphokine。

    公开(公告)号：EP0077571A2

    公开(公告)日：1983-04-27

    申请号：EP82109658.3

    申请日：1982-10-19

    申请人： AJINOMOTO CO., INC. ,  Hamaoka, Toshiyuki

    发明人： Hamaoka, Toshiyuki ,  Takatsu, Kiyoshi ,  Yoshimoto, Ryota ,  Hamuro, Junji

    IPC分类号： C12F1/00 ,  C12N15/00 ,  C12P21/00

    CPC分类号： C12N5/163 ,  C07K14/53 ,  C07K14/55 ,  C07K14/57

    摘要： A lymphokine in purified form or in the form of a lymphokine containing culture supernatant may be obtained by collecting lymphocytes from an animal or a human sensitized by an immunogen which induces the production of an antibody, selectively concentrating the lymphokine producing cells, forming a fused cell hybrid between the lymphokine producing cells and animal derived tumor cells, cloning the obtained hybrid, selecting the clone which spontaneously produces the lymphokine, culturing the clone to produce the lymphokine, and optionally recovering the lymphokine from the culture and purifying the lymphokine. This process is especially effective for producing interleukin 2, colony stimulating factor, T cells replacing factor, macrophage activating factor or immune interferon.

    摘要翻译： 纯化形式的淋巴细胞因子或含有淋巴因子的培养上清液的形式可以通过从诱导产生抗体，免疫原致敏的动物或人体中收集淋巴细胞来获得，所述免疫原诱导产生抗体，选择性浓缩产生淋巴细胞因子的细胞，形成融合细胞 在产生淋巴因子的细胞和动物来源的肿瘤细胞之间进行杂交，克隆获得的杂交体，选择自发产生淋巴因子的克隆，培养克隆以产生淋巴因子，以及任选地从培养物中回收淋巴因子并纯化淋巴因子。 该过程对于产生白介素2，集落刺激因子，T细胞替代因子，巨噬细胞活化因子或免疫干扰素特别有效。

    Use of ethylamine derivatives as antihypertensive agents
    6.
    发明公开
    Use of ethylamine derivatives as antihypertensive agents 失效
    Verwendung vonÄthylamin-Derivaten als antihypertensive Wirkstoffe。

    公开(公告)号：EP0294183A1

    公开(公告)日：1988-12-07

    申请号：EP88305012.2

    申请日：1988-06-01

    申请人： AJINOMOTO CO., INC.

    发明人： Syoji, Masataka ,  Eguchi, Chikahiko ,  Toyota, Kozo ,  Yoshimoto, Ryota ,  Koyama, Yosikatsu ,  Domoto, Hideki ,  Kamimura, Akira

    IPC分类号： C07D211/32 ,  C07D211/22 ,  C07D211/18 ,  C07D285/24 ,  C07D401/06 ,  A61K31/445 ,  A61K31/54

    CPC分类号： C07D401/06 ,  C07D211/32 ,  C07D285/24 ,  C07D409/06

    摘要： Novel ethylamine derivatives of the formula (I) and salts thereof are useful as antihypertensive agents.
    wherein A is a linking group wherein the linkage is formed by a carbon or nitrogen atom; B is an aryl-containing group; C is hydrogen or optionally substituted alkyl, aralkyl or aryl, or C may be bonded to A to form an optionally substituted alkylene bridge; Q is an aryl- or heterocyclic aryl-containing group; X is a linking group wherein the linkage is formed by optionally substituted alkylene having from 2 to 20 carbon atoms and/or one or more hetero atoms selected from nitrogen and sulfur.

    摘要翻译： 新的式（I）乙胺衍生物及其盐可用作抗高血压药。 其中A是连接基，其中连接是由碳或氮原子形成的; B是含芳基的基团; C是氢或任选取代的烷基，芳烷基或芳基，或C可以与A键合以形成任选取代的亚烷基桥; Q是含芳基或杂环芳基的基团; X是连接基团，其中连接是由具有2至20个碳原子的任选取代的亚烷基和/或一个或多个选自氮和硫的杂原子形成的。