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公开(公告)号：EP0089062A2
公开(公告)日：1983-09-21
申请号：EP83102562.2
申请日：1983-03-15
申请人： AJINOMOTO CO., INC.
CPC分类号： C07K14/55 , A61K31/716 , A61K38/00 , A61K38/21 , A61K39/00 , A61K2300/00
摘要： Interleukin 2 of human cell origin, which has a specific activity of more than 2 x 10 5 units/mg protein and is free from other human lymphokines and monokines is a useful immunoprophylactic and immunotherapeutic agent per se or in combination with other chemotherapeutic agents and/or other immunotherapeutic agents.
摘要翻译： 具有超过2×10 5单位/ mg蛋白质的比活性且不含其他人类淋巴因子和单核因子的人细胞来源的白细胞介素2本身是一种有用的免疫预防和免疫治疗剂，或与其它化学治疗剂组合 和/或其它免疫治疗剂。
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公开(公告)号：EP0118617A3
公开(公告)日：1985-11-13
申请号：EP83112661
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
摘要： Interleukin-2 polypeptides, which are free from substances produced by human cells, are provided. These interleukin-2 polypeptides are produced by a culture of cells of Escherichia coli, constructed by gene-recombination technique, into which a plasmid comprising the genetic information for the synthesis of human IL-2, has been inserted.
摘要翻译： 提供了不含人类细胞产生的物质的白细胞介素-2多肽。 这些白细胞介素-2多肽是通过基因重组技术构建的大肠杆菌细胞培养物产生的，其中已经插入了包含合成人IL-2的遗传信息的质粒。
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3.发明公开Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效多肽白细胞介素2编码基因，含有这种基因的重组DNA，所述重组DNA包含细胞系和方法，用于生产白细胞介素-2的使用所述细胞。
公开(公告)号：EP0091539A1
公开(公告)日：1983-10-19
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
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4.发明授权Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效多肽白细胞介素2编码基因，含有这种基因的重组DNA，所述使用所述细胞的重组DNA，包括细胞系和方法，用于生产白细胞介素-2
公开(公告)号：EP0091539B2
公开(公告)日：1996-11-27
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
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公开(公告)号：EP0089062B1
公开(公告)日：1990-12-05
申请号：EP83102562.2
申请日：1983-03-15
申请人： AJINOMOTO CO., INC.
CPC分类号： C07K14/55 , A61K31/716 , A61K38/00 , A61K38/21 , A61K39/00 , A61K2300/00
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公开(公告)号：EP0118617B1
公开(公告)日：1991-08-21
申请号：EP83112661.0
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
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7.发明授权Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效用于INTERLEUKIN-2多肽的基因编码，携带所述基因的重组DNA，重组DNA的细胞系以及使用所述细胞产生白细胞介素-2的方法
公开(公告)号：EP0091539B1
公开(公告)日：1988-07-13
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
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公开(公告)号：EP0089062A3
公开(公告)日：1986-02-05
申请号：EP83102562
申请日：1983-03-15
申请人： AJINOMOTO CO., INC.
CPC分类号： C07K14/55 , A61K31/716 , A61K38/00 , A61K38/21 , A61K39/00 , A61K2300/00
摘要： Interleukin 2 of human cell origin, which has a specific activity of more than 2 x 10 5 units/mg protein and is free from other human lymphokines and monokines is a useful immunoprophylactic and immunotherapeutic agent per se or in combination with other chemotherapeutic agents and/or other immunotherapeutic agents.
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公开(公告)号：EP0118617A2
公开(公告)日：1984-09-19
申请号：EP83112661.0
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
摘要： Interleukin-2 polypeptides, which are free from substances produced by human cells, are provided. These interleukin-2 polypeptides are produced by a culture of cells of Escherichia coli, constructed by gene-recombination technique, into which a plasmid comprising the genetic information for the synthesis of human IL-2, has been inserted.
摘要翻译： 提供了不含人细胞产生的物质的白细胞介素-2多肽。 通过基因重组技术构建的包含用于合成人IL-2的遗传信息的质粒的质粒的培养产生这些白细胞介素-2多肽。
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