公开(公告)号：EP1193255A4

公开(公告)日：2002-08-07

申请号：EP00940879

申请日：2000-06-29

申请人： AJINOMOTO KK

发明人： IINO YUKIO ,  FUJITA KOHICHI ,  KODAIRA ARIKO ,  HATANAKA TOSHIHIRO ,  TAKEHANA KENJI ,  KOBAYASHI TSUYOSHI ,  KONISHI ATSUSHI ,  YAMAMOTO TAKASHI

IPC分类号： A61P29/00 ,  C07D211/58 ,  C07D213/75 ,  C07D237/22 ,  C07D239/48 ,  C07D277/44 ,  C07D277/46 ,  A61K31/44 ,  A61K31/445 ,  A61K31/50 ,  C07D213/76

CPC分类号： C07D213/75 ,  C07D211/58 ,  C07D237/22 ,  C07D239/48 ,  C07D277/46

摘要： Heterocyclic compounds represented by the following general formula which have inhibitory effects on AP-1 activity, NF-Kappa B activity, inflammatory cytokine production, matrix metalloprotease production, inflammatory cell adhesion factor expression, etc. and are usable as drugs: R1-C(=O)-N(R2)-A-X-B-N(R3)-Y-(CH¿2)n-R?4 wherein R1 represents cycloalkyl or cycloalkenyl; R?2 and R3¿ represent each hydrogen or alkyl; R4 represents alkyl, a heterocycle, etc.; n is an integer of from 0 to 6; A represents a heterocycle; B represents an aromatic ring or a heterocycle; and X and Y represent each a bond or a linking group.

公开(公告)号：EP2108367A4

公开(公告)日：2010-03-03

申请号：EP07850505

申请日：2007-12-12

申请人： AJINOMOTO KK

发明人： NISHITANI SHINOBU ,  TAKEHANA KENJI

IPC分类号： A61K31/198 ,  A23L1/305 ,  A61P21/00 ,  A61P43/00

CPC分类号： A61K31/198 ,  A23L33/175

公开(公告)号：EP1912065A4

公开(公告)日：2011-01-26

申请号：EP06782218

申请日：2006-07-27

申请人： AJINOMOTO KK

发明人： KUBOTA KAZUYUKI ,  YAMADA NAOYUKI ,  TAKEHANA KENJI ,  KAWAKAMI ASAMI ,  NAKAYAMA AKIRA

IPC分类号： G01N30/88 ,  G01N27/62 ,  G01N30/04 ,  G01N30/26 ,  G01N30/72

CPC分类号： G01N30/88 ,  G01N2030/8813 ,  G01N2030/8822 ,  G01N2030/8831

公开(公告)号：EP1211240A4

公开(公告)日：2003-02-12

申请号：EP00956838

申请日：2000-08-31

申请人： AJINOMOTO KK

发明人： IINO YUKIO ,  FUJITA KOHICHI ,  YAMAMOTO TAKASHI ,  TAKEHANA KENJI ,  KOBAYASHI TSUYOSHI

IPC分类号： A61P29/00 ,  A61P31/12 ,  A61P35/04 ,  A61P37/06 ,  A61P43/00 ,  C07C233/60 ,  C07C233/62 ,  C07C317/22 ,  C07D213/75 ,  A61K31/167 ,  A61K31/44

CPC分类号： C07D213/75 ,  C07C233/60 ,  C07C233/62 ,  C07C317/22 ,  C07C2601/02

摘要： Biscyclopropanecarboxylic acid amide compounds represented by general formula (I) and NF-kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion factor expression inhibitors and antiinflammatory agents, antirheumatic agents, immunosuppressors, cancer metastasis inhibitors or antiviral agents containing the above compounds as the active ingredient: (I) wherein R1 to R4 represent each methyl, etc.; R5 and R6 represent each hydrogen, etc.; andUS0023405sent a group represented by one of general formulae (II) to (V): wherein B1 to B10 represent each an aromatic ring or an aromatic heterocycle; and -X1- to -X6- represent each an interatomic bond, etc.

公开(公告)号：EP2813224A4

公开(公告)日：2015-06-24

申请号：EP13747280

申请日：2013-02-06

申请人： AJINOMOTO KK ,  NAT UNIV CORP TOKYO MED & DENT

发明人： KOHSAKA HITOSHI ,  TAKEHANA KENJI ,  TAGATA YUSUKE

IPC分类号： A61K31/198 ,  A61P21/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00

CPC分类号： A61K31/198 ,  A61K9/0053 ,  A61K2300/00

摘要： The present invention aims to provide a prophylactic or therapeutic agent for idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment. The present invention provides a prophylactic or therapeutic agent for idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment, which contains isoleucine, leucine and valine as active ingredients.

摘要翻译： 本发明旨在提供特发性炎症性肌病或与类固醇诱导的肌病相关的特发性炎症性肌病在治疗过程中发展的预防或治疗剂。 本发明提供特发性炎症性肌病或与类固醇诱发的肌病相关的特发性炎性肌病的预防或治疗剂，其在治疗过程中发展，其含有异亮氨酸，亮氨酸和缬氨酸作为活性成分。

公开(公告)号：EP1832284A4

公开(公告)日：2008-07-30

申请号：EP05822407

申请日：2005-12-28

申请人： AJINOMOTO KK

发明人： TAKEHANA KENJI ,  MITSUI AKIRA ,  ISHIDA NOZOMU ,  FUKUCHI NAOYUKI ,  MAEZONO KATSUMI

IPC分类号： A61K31/198 ,  A23L1/305 ,  A23L2/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P9/00 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00

CPC分类号： A61K31/198 ,  A23L33/175 ,  A61K31/519 ,  A61K45/06

摘要： An adiponectin inducer or adiponectin secretagogue, comprising an amino acid selected from among leucine, isoleucine, valine, methionine, cysteine, alanine and mixtures thereof. Further, there is provided a therapeutic agent for hypoadiponectinemia, hyperlipemia, hypertension or angiopathy, or an antiinflammatory agent, comprising the adiponectin inducer or adiponectin secretagogue.