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    BOTULINUM TOXIN DOSAGE REGIMEN FOR CHRONIC MIGRAINE PROPHYLAXIS
    1.
    发明公开
    BOTULINUM TOXIN DOSAGE REGIMEN FOR CHRONIC MIGRAINE PROPHYLAXIS 审中-公开

    公开(公告)号：EP4140499A1

    公开(公告)日：2023-03-01

    申请号：EP22184142.2

    申请日：2011-03-29

    申请人： ALLERGAN, INC.

    发明人： Turkel, Catherine C. ,  Aurora, Sheena K. ,  Dodick, David W. ,  Brin, Mitchell F.

    IPC分类号： A61K38/48 ,  A61P25/24

    摘要： Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering from chronic migraine. The injection schedule requires a minimum dose of 155 U using a fixed-site, fixed-dose injection regimen into 31-39 sites across 7 head/nech muscles, namely the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles.

    Botulinum toxin dosage regimen for depression
    3.
    发明公开
    Botulinum toxin dosage regimen for depression 审中-公开
    DosierschemafürBotulinumtoxin zur Vorbeugung von chronischerMigräne

    公开(公告)号：EP2735313A1

    公开(公告)日：2014-05-28

    申请号：EP14156327.0

    申请日：2011-03-29

    申请人： Allergan, Inc.

    发明人： Turkel, Catherine C. ,  Aurora, Sheena K. ,  Dodick, David W. ,  Brin, Mitchell F.

    IPC分类号： A61K38/48 ,  A61P25/24

    CPC分类号： A61K38/4893 ,  A61K9/0019 ,  A61K35/74 ,  C07K14/33 ,  C12Y304/24069

    摘要： Disorders such as depression can be treated by administration of a botulinum toxin to a patient suffering therefrom. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients.

    摘要翻译： 诸如抑郁症等疾病可以通过向患有这种药物的患者施用肉毒杆菌毒素来治疗。 公开了固定部位/固定剂量和可选的疼痛变量剂量和注射部位范例的组合，以优化患者的肉毒杆菌毒素给药的临床有效性。

    BOTULINUM TOXIN DOSAGE REGIMEN FOR CHRONIC MIGRAINE PROPHYLAXIS
    9.
    发明公开
    BOTULINUM TOXIN DOSAGE REGIMEN FOR CHRONIC MIGRAINE PROPHYLAXIS 审中-公开
    慢性偏头痛预防的肉毒杆菌毒素剂量规律

    公开(公告)号：EP3311831A1

    公开(公告)日：2018-04-25

    申请号：EP17189376.1

    申请日：2011-03-29

    申请人： ALLERGAN, INC.

    发明人： Turkel, Catherine C. ,  Aurora, Sheena K. ,  Dodick, David W. ,  Brin, Mitchell F.

    IPC分类号： A61K38/48 ,  A61K35/74 ,  A61P25/06

    CPC分类号： A61K38/4893 ,  A61K9/0019 ,  A61K35/74 ,  C07K14/33 ,  C12Y304/24069

    摘要： Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering from chronic migraine. The injection schedule requires a minimum dose of 155 U using a fixed-site, fixed-dose injection regimen into 31-39 sites across 7 head/nech muscles, namely the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles.

    摘要翻译： 诸如头痛之类的疾病可以通过向患有偏头痛的患者施用肉毒杆菌毒素来治疗。 公开了一种固定部位/固定剂量和任选的组合，其遵循疼痛可变剂量和注射部位范例，用于优化患有慢性偏头痛的患者的肉毒杆菌毒素施用的临床效果。 注射时间表需要使用固定部位固定剂量注射方案的最小剂量为155U，穿过7头/内侧肌肉的31-39个部位，即额骨，皱眉器，前掌，枕骨，颞骨，斜方肌和颈椎旁肌 。