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1.发明授权INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY 有权吲哚-3-甲酰胺，酯，硫代酰胺和THIOLESTERVERBINDUNGEN与具有生物鞘氨醇-1-磷酸的芳基或杂芳基（S1P）-REZEPTORANTAGONISTENWIRKUNG
公开(公告)号：EP1984334B1
公开(公告)日：2014-04-09
申请号：EP07756963.0
申请日：2007-02-14
申请人： ALLERGAN, INC.
发明人： BEARD, Richard, L. , DONELLO, John, E. , YUAN, Haiqing , LIU, Xiaoxia , DUONG, Tien , COLON, Diana, F. , HU, Yihui
IPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04
CPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06
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2.发明公开INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY 有权吲哚-3-甲酰胺，酯，硫代酰胺和THIOLESTERVERBINDUNGEN与具有生物鞘氨醇-1-磷酸的芳基或杂芳基（S1P）-REZEPTORANTAGONISTENWIRKUNG
公开(公告)号：EP1984334A2
公开(公告)日：2008-10-29
申请号：EP07756963.0
申请日：2007-02-14
申请人： ALLERGAN, INC.
发明人： BEARD, Richard, L. , DONELLO, John, E. , YUAN, Haiqing , LIU, Xiaoxia , DUONG, Tien , COLON, Diana, F. , HU, Yihui
IPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04
CPC分类号： C07D209/42 , C07D401/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06
摘要： The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, A, X, Z, R1, o, R3, R2 and p are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
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