公开(公告)号：EP2932968B1

公开(公告)日：2018-01-17

申请号：EP15165926.5

申请日：2009-06-05

申请人： ALLERGAN, INC.

发明人： Fang, Wenkui K. ,  Nguyen, Phong X. ,  Chow, Ken ,  Heidelbaugh, Todd M. ,  Gomez, Dario G. ,  Garst, Michael E. ,  Sinha, Santosh C. ,  Gil, Daniel W. ,  Donello, John E.

IPC分类号： A61K31/4168 ,  A61P9/12

CPC分类号： A61K31/4168

摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.

公开(公告)号：EP2932968A1

公开(公告)日：2015-10-21

申请号：EP15165926.5

申请日：2009-06-05

申请人： ALLERGAN, INC.

发明人： Fang, Wenkui K. ,  Nguyen, Phong X. ,  Chow, Ken ,  Heidelbaugh, Todd M. ,  Gomez, Dario G. ,  Garst, Michael E. ,  Sinha, Santosh C. ,  Gil, Daniel W. ,  Donello, John E.

IPC分类号： A61K31/4168 ,  A61P9/12

CPC分类号： A61K31/4168

摘要： The present invention provides a compound represented by the following formula, or a pharmaceutically-acceptable salt or tautomer thereof:

wherein R 1 and R 2 are independently selected from halogen and C 1-4 halogenated alkyl. The compound is useful in the treatment of alpha adrenergic mediated conditions such as pain.

摘要翻译： 本发明提供由下式表示的化合物或其药学上可接受的盐或互变异构体：其中R 1和R 2独立地选自卤素和C 1-4卤代烷基。 该化合物可用于治疗α-肾上腺素能介导的病症如疼痛。

公开(公告)号：EP3584237A1

公开(公告)日：2019-12-25

申请号：EP19189773.5

申请日：2010-10-06

申请人： ALLERGAN, INC.

发明人： Chow, Ken ,  Gil, Daniel W. ,  Donello, John E. ,  Wang, Liming ,  Corpuz, Evelyn G. ,  Fang, Wenkui K. ,  Sinha, Santosh C. ,  Dibas, Mohammed I.

IPC分类号： C07D207/22 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/4025 ,  A61P9/00 ,  A61P29/00 ,  A61P27/06 ,  A61P17/00

摘要： Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

公开(公告)号：EP2377534A1

公开(公告)日：2011-10-19

申请号：EP11174152.6

申请日：2009-06-05

申请人： ALLERGAN, INC.

发明人： Fang, Wenkui K. ,  Nguyen, Phong X. ,  Chow, Ken ,  Heidelbaugh, Todd M. ,  Gomez, Dario G. ,  Garst, Michael ,  Sinha, Santosh C.

IPC分类号： A61K31/4168 ,  A61P9/12

CPC分类号： A61K31/4168

摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.

摘要翻译： 本文描述的是用于通过向受试者施用含有有效量的±肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的方法中的化合物。 这些化合物也可用于缓解急性和慢性疼痛的类型。