公开(公告)号：EP3078376B1

公开(公告)日：2019-03-27

申请号：EP16161921.8

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Gil, Daniel W. ,  Chow, Ken ,  Wang, Liming ,  Garst, Michael E. ,  Donello, John E.

IPC分类号： A61K31/4174 ,  A61P27/06

公开(公告)号：EP3050563B1

公开(公告)日：2018-05-09

申请号：EP16161920.0

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Chow, Ken ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  A61P27/06

CPC分类号： A61K31/4174 ,  A61K9/0014 ,  A61K31/4164 ,  C07D233/64 ,  Y10S514/912

摘要： The present invention relates to novel compounds, ester pro-drugs of [3-(1-(1 H -imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals in the treatment of conditions mediated by adrenergic receptors.

公开(公告)号：EP3050563A1

公开(公告)日：2016-08-03

申请号：EP16161920.0

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Chow, Ken ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  A61P27/06

CPC分类号： A61K31/4174 ,  A61K9/0014 ,  A61K31/4164 ,  C07D233/64 ,  Y10S514/912

摘要： The present invention relates to method for treating skin diseases and skin conditions in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, or enantiomers thereof, pharmaceutical compositions containing them and their use as pharmaceuticals.

摘要翻译： 本发明涉及治疗需要这种治疗的受试者皮肤疾病和皮肤病症的方法，其包括给予治疗有效量的包含[3-（1-（1H-咪唑-4-基） - 基）乙基）-2-甲基苯基]甲醇或其对映体，含有它们的药物组合物及其作为药物的用途。

公开(公告)号：EP3636263A1

公开(公告)日：2020-04-15

申请号：EP19194325.7

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Chow, Ken ,  Dibas, Mohammed I. ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  A61P27/06

摘要： The present invention relates to novel compounds, ester pro-drugs of [3-(1-(1 H -imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals in the treatment of conditions mediated by adrenergic receptors.

公开(公告)号：EP3584237A1

公开(公告)日：2019-12-25

申请号：EP19189773.5

申请日：2010-10-06

申请人： ALLERGAN, INC.

发明人： Chow, Ken ,  Gil, Daniel W. ,  Donello, John E. ,  Wang, Liming ,  Corpuz, Evelyn G. ,  Fang, Wenkui K. ,  Sinha, Santosh C. ,  Dibas, Mohammed I.

IPC分类号： C07D207/22 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/4025 ,  A61P9/00 ,  A61P29/00 ,  A61P27/06 ,  A61P17/00

摘要： Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.

公开(公告)号：EP3698789A1

公开(公告)日：2020-08-26

申请号：EP19217499.3

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Chow, Ken ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  C07D233/64 ,  A61P27/06 ,  A61P17/04

摘要： The present invention relates to method of lowering intraocular pressure in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, of enantiomers thereof, of tautomers thereof, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP3050564B1

公开(公告)日：2019-09-04

申请号：EP16161923.4

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Chow, Ken ,  Dibas, Mohammed I. ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  A61P27/06

公开(公告)号：EP3078376A1

公开(公告)日：2016-10-12

申请号：EP16161921.8

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Gil, Daniel W. ,  Chow, Ken ,  Wang, Liming ,  Garst, Michael E. ,  Donello, John E.

IPC分类号： A61K31/4174 ,  A61P27/06

CPC分类号： A61K31/4174 ,  A61K9/0014 ,  A61K31/4164 ,  C07D233/64 ,  Y10S514/912

摘要： The present invention relates to method of treating retinal diseases in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

摘要翻译： 本发明涉及在需要这种治疗的个体中治疗视网膜疾病的方法，其包括给予治疗有效量的包含[3-（1-（1H-咪唑-4-基） ）乙基）-2-甲基苯基]甲醇，其制备方法，含有它们的药物组合物及其作为药物的用途。

公开(公告)号：EP3659600A1

公开(公告)日：2020-06-03

申请号：EP20153104.3

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Gil, Daniel W. ,  Chow, Ken ,  Wang, Liming ,  Garst, Michael E. ,  Donello, John E.

IPC分类号： A61K31/4174 ,  A61P27/06

摘要： The present invention relates to method of treating retinal diseases in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP3348264B1

公开(公告)日：2020-01-01

申请号：EP18160174.1

申请日：2011-09-16

申请人： ALLERGAN, INC.

发明人： Dibas, Mohammed I. ,  Chow, Ken ,  Donello, John E. ,  Garst, Michael E. ,  Gil, Daniel W. ,  Wang, Liming

IPC分类号： A61K31/4174 ,  C07D233/64 ,  A61P27/06 ,  A61P17/04