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公开(公告)号：EP2023937A4
公开(公告)日：2009-10-28
申请号：EP07797577
申请日：2007-05-18
IPC分类号： A61K31/70 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/3515
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公开(公告)号：EP1941059A4
公开(公告)日：2010-11-03
申请号：EP06827135
申请日：2006-10-27
发明人： SAH DINAH WEN-YEE , HADWIGER PHILIPP , ROEHL INGO , BRAMLAGE BIRGIT , TAN PAMELA , VORNLOCHER HANS-PETER , BUMCROT DAVID
IPC分类号： A61K31/713 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
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3.发明公开
公开(公告)号：EP2021507A4
公开(公告)日：2009-10-28
申请号：EP07762085
申请日：2007-05-10
发明人： TAN PAMELA , BRAMLAGE BIRGIT , FRANK-KAMENETSKY MARIA , FITZGERALD KEVIN , AKINC AKIN , KOTELIANSKI VICTOR E
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human PCSK9 gene in a cell, wherein said dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising a region of complementarity which is substantially complementary to at least a part of a mRNA encoding PCSK9, and wherein said region of complementarity is less than 30 nucleotides in length and wherein said dsRNA, upon contact with a cell expressing said PCSK9, inhibits expression of said PCSK9 gene, wherein (a) said first sequence is the sequence of SEQ ID NO: 1229 and said second sequence is the sequence of SEQ ID NO: 1230; (b) said first sequence is the sequence of SEQ ID NO: 1227 and said second sequence is the sequence of SEQ ID NO: 1228; or (c) said part of said mRNA encoding PCSK9 is the sequence from position 3530 to 3548 of the mRNA sequence of database entry NM_174936.
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公开(公告)号：EP1896084A4
公开(公告)日：2010-10-20
申请号：EP06785707
申请日：2006-06-27
发明人： AKINC AKIN , DE FOUGEROLLES ANTONIN , VORNLOCHER HANS-PETER , HADWIGER PHILIPP , BRAMLAGE BIRGIT
IPC分类号： A61K31/713 , A61P27/02 , C12N15/113 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521
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5.发明公开COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS 有权组合物和方法抑制基因的表达FROM THE JC病毒
公开(公告)号：EP2013222A4
公开(公告)日：2009-10-21
申请号：EP07761452
申请日：2007-04-27
发明人： TAN PAMELA , SAH DINAH , BRAMLAGE BIRGIT
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , A61K48/005 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3521
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