公开(公告)号：EP0973499B1

公开(公告)日：2003-08-06

申请号：EP98911690.0

申请日：1998-03-17

申请人： ALZA CORPORATION

发明人： ROORDA, Wouter, E. ,  DIONNE, Keith, E. ,  BROWN, James, E. ,  WRIGHT, Jeremy, C. ,  DAVIS, Craig, R. ,  PRESTRELSKI, Steven, J. ,  TZANNIS, Stelios, T.

IPC分类号： A61K9/00

CPC分类号： A61K9/0024 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/145 ,  A61K31/445 ,  A61K31/675 ,  A61K47/26

公开(公告)号：EP1044032A2

公开(公告)日：2000-10-18

申请号：EP98963214.6

申请日：1998-12-15

申请人： ALZA CORPORATION

发明人： DAVIS, Craig, R. ,  PEERY, John, R.

IPC分类号： A61M36/12

CPC分类号： A61M37/0069 ,  A61J1/00

摘要： An implanter for inserting subcutaneous implants includes a handle for grasping the implanter during implantation, a hollow cannula receiving the implant, and a rod for releasing the implant from the cannula. The rod is longitudinally fixed within the handle while the cannula slides over the rod to release the implant. The cannula is moved over the rod by a sliding actuator mounted in a track of the handle. The actuator is locked in an extended position to prevent unintended release of the implant. Preferably, the implanter is a single-use device having an actuator locking feature preventing reuse.

公开(公告)号：EP0973499A1

公开(公告)日：2000-01-26

申请号：EP98911690.0

申请日：1998-03-17

申请人： ALZA CORPORATION

发明人： ROORDA, Wouter, E. ,  DIONNE, Keith, E. ,  BROWN, James, E. ,  WRIGHT, Jeremy, C. ,  DAVIS, Craig, R. ,  PRESTRELSKI, Steven, J. ,  TZANNIS, Stelios, T.

IPC分类号： A61K9/00

CPC分类号： A61K9/0024 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/145 ,  A61K31/445 ,  A61K31/675 ,  A61K47/26

摘要： A sustained release delivery system for delivering a beneficial agent is provided. The system includes a reservoir comprising the beneficial agent and a capillary channel in communication with the reservoir and the exterior of the system for delivering the beneficial agent from the system. The capillary channel has a cross-sectional area and a length selected to deliver the beneficial agent at a predetermined rate. The system may further include an outer surface that is impermeable and non-porous during delivery of the beneficial agent. The beneficial agent may be formulated in a glassy sugar matrix.

公开(公告)号：EP1246662B1

公开(公告)日：2005-08-31

申请号：EP00984484.6

申请日：2000-12-13

申请人： ALZA CORPORATION

发明人： FERREIRA, Pamela ,  DAVIS, Craig, R. ,  BERRY, Stephen, A. ,  STEWART, Gregory, R. ,  MAGRUDER, Judy, A. ,  LAU, Li-Ming ,  MAGRUDER, Paul, R. ,  HARRISON, Juan, M. ,  ROORDA, Wouter

IPC分类号： A61M39/02 ,  A61K9/00

CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M37/00

摘要： An osmotic beneficial agent delivery system includes an implantable osmotic delivery device and a catheter for delivery of the beneficial agent from the delivery device to a delivery location. The beneficial agent delivery system includes a catheter and a docking station which are implanted in the patient with a distal end of the catheter positioned at a delivery site. The catheter and docking station are left in place while an implant containing the beneficial agent is removably connected to the catheter at the docking station and can be replaced as needed. The docking station provides a connection between a catheter and the implant allowing the implant to be replaced periodically while the catheter and the docking station remain in place.

公开(公告)号：EP0998273A2

公开(公告)日：2000-05-10

申请号：EP98935754.6

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： PETERSON, Lewis, L. ,  MARUYAMA, Frederick, H. ,  DEHNAD, Houdin ,  HOM, Lawton ,  LY, Kevin, s. ,  DAVIS, Craig, R. ,  PEERY, John, R.

IPC分类号： A61K9/52

CPC分类号： A61M5/14276 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14526 ,  A61M5/16813 ,  Y10T29/494

摘要： An osmotic delivery system flow modulator assembly, an osmotic delivery system with a flow modulator assembly, and a method of assembling an osmotic delivery system. The osmotic delivery system flow modulator assembly includes a body having a hole located through the body and communicating two opposing ends of the body. The use of the osmotic delivery system flow modulator assembly lessens the chance that air or gas pockets will form in the enclosure of the osmotic delivery system during assembly of the system. Because less air is within the osmotic delivery system, performance of the system is enhanced. Use of the flow modulator assembly also lessens the chance that beneficial agent will be wasted during assembly of the osmotic delivery system.

公开(公告)号：EP0998273B1

公开(公告)日：2004-09-22

申请号：EP98935754.6

申请日：1998-07-24

申请人： ALZA CORPORATION

发明人： PETERSON, Lewis, L. ,  MARUYAMA, Frederick, H. ,  DEHNAD, Houdin ,  HOM, Lawton ,  LY, Kevin, s. ,  DAVIS, Craig, R. ,  PEERY, John, R.

IPC分类号： A61K9/52

CPC分类号： A61M5/14276 ,  A61K9/0004 ,  A61M5/141 ,  A61M5/14526 ,  A61M5/16813 ,  Y10T29/494

公开(公告)号：EP1044032B1

公开(公告)日：2004-04-21

申请号：EP98963214.6

申请日：1998-12-15

申请人： Alza Corporation

发明人： DAVIS, Craig, R. ,  PEERY, John, R.

IPC分类号： A61M36/12

CPC分类号： A61M37/0069 ,  A61J1/00

摘要： An implanter for inserting subcutaneous implants includes a handle for grasping the implanter during implantation, a hollow cannula receiving the implant, and a rod for releasing the implant from the cannula. The rod is longitudinally fixed within the handle while the cannula slides over the rod to release the implant. The cannula is moved over the rod by a sliding actuator mounted in a track of the handle. The actuator is locked in an extended position to prevent unintended release of the implant. Preferably, the implanter is a single-use device having an actuator locking feature preventing reuse.

公开(公告)号：EP1246662A1

公开(公告)日：2002-10-09

申请号：EP00984484.6

申请日：2000-12-13

申请人： ALZA Corporation

发明人： FERREIRA, Pamela ,  DAVIS, Craig, R. ,  BERRY, Stephen, A. ,  STEWART, Gregory, R. ,  MAGRUDER, Judy, A. ,  LAU, Li-Ming ,  MAGRUDER, Paul, R. ,  HARRISON, Juan, M. ,  ROORDA, Wouter

IPC分类号： A61M39/02 ,  A61K9/00

CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61M37/00

摘要： An osmotic beneficial agent delivery system includes an implantable osmotic delivery device and a catheter for delivery of the beneficial agent from the delivery device to a delivery location. The beneficial agent delivery system includes a catheter and a docking station which are implanted in the patient with a distal end of the catheter positioned at a delivery site. The catheter and docking station are left in place while an implant containing the beneficial agent is removably connected to the catheter at the docking station and can be replaced as needed. The docking station provides a connection between a catheter and the implant allowing the implant to be replaced periodically while the catheter and the docking station remain in place.