ONCE-A-DAY, ORAL, CONTROLLED-RELEASE, OXYCODONE DOSAGE FORMS
    2.
    发明公开
    ONCE-A-DAY, ORAL, CONTROLLED-RELEASE, OXYCODONE DOSAGE FORMS 审中-公开
    每日一次口服羟考酮的剂量控释

    公开(公告)号:EP1677798A2

    公开(公告)日:2006-07-12

    申请号:EP04817492.4

    申请日:2004-10-28

    申请人: ALZA CORPORATION

    IPC分类号: A61K31/485

    摘要: Oxycodone formulations are provided which produce substantially flat in vivo steady state plasma profiles. Tolerance levels associated with such profiles and tolerance levels associated with biphasic profiles are shown not to be statistically different. The substantially flat in vivo steady state plasma profiles are produced by dosage forms having substantially zero order in vitro release profiles. Such release profiles produce low single dose in vivo Cmax levels which can reduce the probability of adverse side effects.