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公开(公告)号：EP1117383A1
公开(公告)日：2001-07-25
申请号：EP99948122.9
申请日：1999-09-03
申请人： ALZA CORPORATION
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a substained-release period of time up to 24 hours.
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2.发明授权
公开(公告)号：EP0936893B1
公开(公告)日：2001-06-20
申请号：EP97912756.0
申请日：1997-10-14
申请人： ALZA Corporation
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0004
摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member (10) having first and second ends (12, 14) comprises first (16) and second (26, 28, 30, 32) flow paths. Either of both of said flow paths contains an active agent (18). Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
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3.发明公开OSMOTIC DEVICE WITH HIGH DRUG LOADING AND DELAYED ACTIVATION OF DRUG DELIVERY 失效与活性物质含量高，渗透装置和延迟启用主动释放
公开(公告)号：EP0828477A1
公开(公告)日：1998-03-18
申请号：EP96914624.0
申请日：1996-05-13
申请人： ALZA CORPORATION
发明人： WONG, Patrick, S., L. , DONG, Liang, C. , FERRARI, Vincent, J. , WRIGHT, Jeri, D. , LARSEN, Steven, D.
IPC分类号： A61K9
CPC分类号： A61K9/0004 , Y10S514/962
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably ovoid in shape.
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公开(公告)号：EP0984762B1
公开(公告)日：2002-08-07
申请号：EP98920955.6
申请日：1998-05-07
申请人： ALZA CORPORATION
发明人： WONG, Patrick, S.-L. , FERRARI, Vincent, J. , ETTER, Jeffrey, W. , MARTIN, Miriam, A. , ROTH, Nathan , OHMS, Christopher, M., G. , POUTIATINE, Andrew, I. , HORVATH, James, W.
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
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5.发明公开
公开(公告)号：EP0936893A1
公开(公告)日：1999-08-25
申请号：EP97912756.0
申请日：1997-10-14
申请人： ALZA CORPORATION
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0004
摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member (10) having first and second ends (12, 14) comprises first (16) and second (26, 28, 30, 32) flow paths. Either of both of said flow paths contains an active agent (18). Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
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公开(公告)号：EP0936894B1
公开(公告)日：2001-09-12
申请号：EP97912765.1
申请日：1997-10-14
申请人： ALZA Corporation
发明人： HORVATH, James, W. , FERRARI, Vincent, J. , WONG, Patrick, S., -L. , ANTHONY, Joyce, C. , VUKADIN, Radomir, N., M. , ETTER, Jeffrey, W. , OHMS, Christopher, M., G.
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member (10) having first (12) and second (14) ends. The closure system includes a deformable closure means (28) adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
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公开(公告)号：EP0984762A1
公开(公告)日：2000-03-15
申请号：EP98920955.6
申请日：1998-05-07
申请人： ALZA CORPORATION
发明人： WONG, Patrick, S.-L. , FERRARI, Vincent, J. , ETTER, Jeffrey, W. , MARTIN, Miriam, A. , ROTH, Nathan , OHMS, Christopher, M., G. , POUTIATINE, Andrew, I. , HORVATH, James, W.
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
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公开(公告)号：EP1117383B1
公开(公告)日：2005-11-23
申请号：EP99948122.9
申请日：1999-09-03
申请人： ALZA CORPORATION
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a substained-release period of time up to 24 hours.
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9.发明授权OSMOTIC DEVICE WITH HIGH DRUG LOADING AND DELAYED ACTIVATION OF DRUG DELIVERY 失效与活性物质含量高，渗透装置和延迟启用主动释放
公开(公告)号：EP0828477B1
公开(公告)日：2001-11-07
申请号：EP96914624.0
申请日：1996-05-13
申请人： ALZA CORPORATION
发明人： WONG, Patrick, S., L. , DONG, Liang, C. , FERRARI, Vincent, J. , WRIGHT, Jeri, D. , LARSEN, Steven, D.
IPC分类号： A61K9/00
CPC分类号： A61K9/0004 , Y10S514/962
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably ovoid in shape.
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公开(公告)号：EP0810856B1
公开(公告)日：2001-04-11
申请号：EP96907041.6
申请日：1996-02-09
申请人： ALZA Corporation
IPC分类号： A61K9/22
CPC分类号： A61K9/2072
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