-
公开(公告)号：EP1051217B1
公开(公告)日：2003-08-27
申请号：EP98964191.5
申请日：1998-12-21
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
-
公开(公告)号：EP1051217A1
公开(公告)日：2000-11-15
申请号：EP98964191.5
申请日：1998-12-21
申请人： ALZA CORPORATION
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
-
公开(公告)号：EP1011642A2
公开(公告)日：2000-06-28
申请号：EP98937963.1
申请日：1998-07-24
申请人： ALZA CORPORATION
发明人： CHEN, Guohua , DIONNE, Keith, E. , LAUTENBACH, Scott, D. , JORDAN, Scott, D. , BERRY, Stephen, A. , RODENBERGER, Craig, I. , AYER, Rupal
IPC分类号： A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
-
公开(公告)号：EP1011642B1
公开(公告)日：2007-03-28
申请号：EP98937963.1
申请日：1998-07-24
申请人： ALZA CORPORATION
发明人： CHEN, Guohua , DIONNE, Keith, E. , LAUTENBACH, Scott, D. , JORDAN, Scott, D. , BERRY, Stephen, A. , RODENBERGER, Craig, I. , AYER, Rupal
IPC分类号： A61K9/52
CPC分类号： A61K9/0004
摘要： Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
-
公开(公告)号：EP1051217B8
公开(公告)日：2004-07-21
申请号：EP98964191.5
申请日：1998-12-21
申请人： ALZA Corporation
发明人： AYER, Rupal , JORDAN, Scott, D. , STEWART, Gregory, R. , BERRY, Stephen, A. , ECKENHOFF, James, B. DI
CPC分类号： A61K9/0004 , A61K9/0024 , A61M5/1424 , A61M5/1684 , A61M25/0108 , A61M31/002 , A61M2250/00
摘要： Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.
-
-
-
-
搜索结果
5 条记录 (耗时 0.01 秒)
