OSMOTIC DRUG DELIVERY MONITORING SYSTEM
    1.
    发明授权
    OSMOTIC DRUG DELIVERY MONITORING SYSTEM 有权
    系统用于监控OSMOTIC现役DEVICE

    公开(公告)号:EP1051217B1

    公开(公告)日:2003-08-27

    申请号:EP98964191.5

    申请日:1998-12-21

    IPC分类号: A61M37/00 A61K9/00 A61M5/142

    摘要: Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.

    OSMOTIC DELIVERY SYSTEM WITH SEMIPERMEABLE PLUG
    2.
    发明公开
    OSMOTIC DELIVERY SYSTEM WITH SEMIPERMEABLE PLUG 失效
    带插头的半透渗透输送系统

    公开(公告)号:EP1011642A2

    公开(公告)日:2000-06-28

    申请号:EP98937963.1

    申请日:1998-07-24

    申请人: ALZA CORPORATION

    IPC分类号: A61K9/52

    CPC分类号: A61K9/0004

    摘要: Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

    OSMOTIC DELIVERY SYSTEM WITH SEMIPERMEABLE PLUG
    4.
    发明授权
    OSMOTIC DELIVERY SYSTEM WITH SEMIPERMEABLE PLUG 失效
    带插头的半透渗透输送系统

    公开(公告)号:EP1011642B1

    公开(公告)日:2007-03-28

    申请号:EP98937963.1

    申请日:1998-07-24

    申请人: ALZA CORPORATION

    IPC分类号: A61K9/52

    CPC分类号: A61K9/0004

    摘要: Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.

    OSMOTIC DRUG DELIVERY MONITORING SYSTEM AND METHOD
    7.
    发明公开
    OSMOTIC DRUG DELIVERY MONITORING SYSTEM AND METHOD 有权
    方法和系统用于监测OSMOTIC现役DEVICE

    公开(公告)号:EP1051217A1

    公开(公告)日:2000-11-15

    申请号:EP98964191.5

    申请日:1998-12-21

    申请人: ALZA CORPORATION

    IPC分类号: A61M37/00 A61K9/00 A61M5/142

    摘要: Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.

    OSMOTIC DRUG DELIVERY MONITORING SYSTEM
    8.
    发明授权
    OSMOTIC DRUG DELIVERY MONITORING SYSTEM 有权
    系统用于监控OSMOTIC现役DEVICE

    公开(公告)号:EP1051217B8

    公开(公告)日:2004-07-21

    申请号:EP98964191.5

    申请日:1998-12-21

    申请人: ALZA Corporation

    IPC分类号: A61M37/00 A61K9/00 A61M5/142

    摘要: Performance of delivery systems for delivering beneficial agents to an animal are monitored to determine the delivery rate of the beneficial agent and the proper operation of the beneficial agent delivery device. Performance monitoring can be achieved by monitoring the physical configuration of the implanted osmotic delivery device from the exterior of the body to determine the amount of beneficial agent delivered and/or the delivery rate of the beneficial agent. The monitoring of the physical configuration of the implanted osmotic delivery device may be performed in different manners such as by X-ray or fluoroscopic monitoring of the implant structure or magnetic determination of a piston location within the implant. Performance monitoring can also be achieved by use of a performance marker within the beneficial agent to produce a specifically detectable response which can be measured noninvasively in body fluids or by-products.

    OSMOTIC DELIVERY SYSTEM WITH MEMBRANE PLUG RETENTION MECHANISM
    9.
    发明公开
    OSMOTIC DELIVERY SYSTEM WITH MEMBRANE PLUG RETENTION MECHANISM 有权
    带插头的约束机制渗透输送系统

    公开(公告)号:EP1041968A1

    公开(公告)日:2000-10-11

    申请号:EP98963215.3

    申请日:1998-12-15

    申请人: Alza Corporation

    发明人: AYER, Rupal

    IPC分类号: A61K9/00

    CPC分类号: A61K9/0004

    摘要: An osmotic delivery system has a membrane plug retention mechanism which can also be used to control the delivery rate of a beneficial agent from the osmotic delivery system. The osmotic delivery device includes an implant capsule containing a beneficial agent and an osmotic agent. Holes are formed along a side wall of the implant capsule at an open end of the capsule. When the membrane plug is inserted into the open end of the capsule the membrane material swells into the holes in the capsule side wall creating a large frictional force which prevents expulsion of the membrane plug. A beneficial agent delivery rate of the osmotic delivery system is controllable by varying the size and number of the holes to change the amount of exposed surface area of the membrane plug. An increase in the surface area of the membrane plug exposed to the exterior environment causes a corresponding increase in the liquid permeation rate of the membrane and thus, increases the beneficial agent delivery rate.