公开(公告)号：EP1507776B1

公开(公告)日：2007-02-28

申请号：EP03741829.0

申请日：2003-05-29

申请人： AMGEN INC.

发明人： HUANG, Qi ,  KALLER, Matthew ,  NGUYEN, Thomas ,  NORMAN, Mark, H. ,  RZASA, Robert ,  WANG, Hui-Ling ,  ZHONG, Wenge

IPC分类号： C07D417/14 ,  C07D403/04 ,  C07D491/04 ,  C07D417/04 ,  C07D409/14 ,  C07D513/04 ,  C07D471/04 ,  A61K31/505 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D403/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

摘要： Compounds of formula (I) are effective for treatment of cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2569306A1

公开(公告)日：2013-03-20

申请号：EP11731557.2

申请日：2011-05-11

申请人： Amgen Inc.

发明人： ALLEN, Jennifer ,  FROHN, Michael ,  HARRINGTON, Paul ,  PICKRELL, Alexander ,  RZASA, Robert ,  SHAM, Kelvin ,  Harrington, Essa Hu

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4523 ,  A61K31/497 ,  A61K31/506 ,  A61P3/00 ,  A61P25/18

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Heteroaryloxycarbocyclyl compounds of formula (I), and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive -compulsive disorder, and the like. Formula (I)

摘要翻译： 式（I）的杂芳氧基碳环基化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供了治疗可通过抑制PDE10治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相型障碍，强迫症等。 式（I）

公开(公告)号：EP1478645A2

公开(公告)日：2004-11-24

申请号：EP03707786.4

申请日：2003-02-07

申请人： Amgen Inc.

发明人： NORMAN, Mark ,  WANG, Hui-ling ,  RZASA, Robert ,  ZHONG, Wenge ,  NGUYEN, Thomas ,  KALLER, Matthew

IPC分类号： C07D417/00 ,  C07D491/04 ,  C07D471/04 ,  C07D513/04 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

摘要： Selected compounds of formula (I) wherein (a) is (b) or (c) wherein A is O, S or NH; wherein D is CR1 or N; wherein E is CR2 or N; wherein F is CR3 or N; wherein F is CR4 or N; wherein J is selected from NR6, S, O, and CR1 wherein K is selected from NR6 , S, O, and CR2; wherein L is selected from NR6, S, O, and CR3 are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1507776A1

公开(公告)日：2005-02-23

申请号：EP03741829.0

申请日：2003-05-29

申请人： Amgen Inc.

发明人： HUANG, Qi ,  KALLER, Matthew ,  NGUYEN, Thomas ,  NORMAN, Mark, H. ,  RZASA, Robert ,  WANG, Hui-Ling ,  ZHONG, Wenge

IPC分类号： C07D417/14 ,  C07D403/04 ,  C07D491/04 ,  C07D417/04 ,  C07D409/14 ,  C07D513/04 ,  C07D471/04 ,  A61K31/505 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D403/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

摘要： Compounds of formula (I) are effective for treatment of cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.