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    PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY
    3.
    发明公开
    PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY 有权
    药理伴侣治疗肥胖

    公开(公告)号：EP1885366A4

    公开(公告)日：2010-07-14

    申请号：EP06772163

    申请日：2006-06-05

    申请人： AMICUS THERAPEUTICS INC

    发明人： FAN JIAN-QIANG ,  VANLENZANO KEN ,  LEE GARY ,  BOUVIER MICHEL

    IPC分类号： C07K14/72 ,  A61K31/4164 ,  A61K31/495 ,  A61K31/505

    CPC分类号： A61K31/495 ,  A61K9/0053 ,  A61K31/497 ,  A61K31/505

    摘要： The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.