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1763 条记录 (耗时 0.022 秒)

    ASSAY
    7.
    发明授权
    ASSAY 有权

    公开(公告)号：EP2729809B1

    公开(公告)日：2018-10-17

    申请号：EP12731634.7

    申请日：2012-06-22

    申请人： DuPont Nutrition Biosciences ApS

    发明人： ISAKSEN, Mai Faurschou ,  KELLETT-SMITH, Anja Hemmingsen ,  MCLENNAN, Neil ,  GILBERT, Ceinwen ,  KYNEB, Majbritt Hauge

    IPC分类号： G01N33/558 ,  G01N33/573 ,  C12Q1/42

    CPC分类号： G01N33/573 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/42 ,  G01N33/558 ,  G01N2333/914 ,  G01N2333/916 ,  G01N2333/924

    摘要： The present invention discloses an assay device (1) for detecting active enzyme in a sample. Said assay device (1) comprises the following components:—(a) a placement region (10) onto which the sample can be placed; (b) a matrix (20) operably connected to said placement region (10) such that the sample when present (such as placed) on said placement region (10) can migrate along said matrix (20); (c) at least one distinct capture location (30) on said matrix (20), wherein each distinct capture location (30) is distanced away from the placement region (10), and wherein the sample can migrate across said distinct capture location (30); (d) capture means (40) being present at or defining each distinct capture location (30), wherein said capture means (40) are capable of binding to said enzyme such that at least a portion of said sample of said enzyme is retained at at least one distinct capture location (30); and (e) selective indication means (50), or at least a component thereof, to provide selective indication of the presence of active enzyme bound to said capture means (40).

    TREATMENT OF PROTEINOPATHIES
    9.
    发明授权
    TREATMENT OF PROTEINOPATHIES 有权

    公开(公告)号：EP2723384B1

    公开(公告)日：2018-08-29

    申请号：EP12802206.8

    申请日：2012-06-22

    申请人： The General Hospital Corporation

    发明人： KRAINC, Dmitri ,  MAZZULLI, Joseph, R.

    IPC分类号： A61K47/00 ,  A61P25/28 ,  G01N33/573

    CPC分类号： C07D487/04 ,  C12Q1/34 ,  C12Q1/44 ,  G01N33/5008 ,  G01N33/573 ,  G01N2333/924 ,  G01N2500/10 ,  Y02A50/57

    摘要： The present disclosure provides technologies relating to lysosomal activation. The disclosure provides several strategies for increasing level and/or activity of lysosomal enzyme, and furthermore demonstrates the surprising applicability of such strategies in the treatment and/or prophylaxis of certain proteinopathies. Among other things, the present invention provides methods and compositions for the treatment and/or prophylaxis of proteinopathies other than lysosomal storage diseases through lysosomal activation. In particular, the present disclosure provides methods and compositions for the treatment and/or prophylaxis of neurodegenerative proteinopathies, and in particular those associated with accumulation of α-synuclein. The present disclosure specifically provides methods and compositions for the treatment and/or prophylaxis of Parkinson's disease.

    KIT AND METHODS FOR THE RAPID DETECTION OF THE ABSENCE OR PRESENCE OF A BETA-LACTAMASE IN SAMPLES OF BODY FLUIDS
    10.
    发明公开
    KIT AND METHODS FOR THE RAPID DETECTION OF THE ABSENCE OR PRESENCE OF A BETA-LACTAMASE IN SAMPLES OF BODY FLUIDS 审中-公开

    公开(公告)号：EP3359681A1

    公开(公告)日：2018-08-15

    申请号：EP16790276.6

    申请日：2016-10-07

    申请人： Université de Fribourg

    发明人： NORDMANN, Patrice ,  POIREL, Laurent ,  KIEFFER, Nicolas

    IPC分类号： C12Q1/04 ,  C12Q1/34

    CPC分类号： C12Q1/04 ,  C12Q1/34

    摘要： The present invention concerns a kit and methods for the detection of absence or presence of a ²-lactamase, for example a penicillinase, in a urine sample taken from a patient suffering from a urinary tract infection. In some embodiments, the goal of the invention is to rapidly identify urinary tract infections which can be treated effectively with a penicillin compound. The invention contributes to slowing down the occurrence of resistances to last generation antibiotics. This is achieved by using penicillin compounds for treating urinary tract infections whenever this can be done efficiently. In brief, the present invention provides a tool for maximizing the use and efficiency of penicillin antibiotics. In other embodiments, the test kit of the invention can be used to detect cephalosporinases or carbapenemases.