公开(公告)号：EP3162793A1

公开(公告)日：2017-05-03

申请号：EP16752647

申请日：2016-02-15

申请人： AMOREPACIFIC CORP

发明人： WOO BYOUNG YOUNG ,  LEE KI-WHA ,  SHIN KWANG-HYUN ,  PARK MIYOUNG ,  JUNG KYOUNGMI ,  CHOI JOONHO ,  CHOI GYEYOUNG ,  CHO WONKYUNG ,  PARK YOUNG-HO

IPC分类号： C07C303/36 ,  C07C303/42 ,  C07C311/08

CPC分类号： C07C303/42 ,  C07B57/00 ,  C07B2200/07 ,  C07C63/06 ,  C07C303/36 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

摘要： The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O' -diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O' -di- p -toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

摘要翻译： 本说明书涉及立体异构体混合物的手性拆分方法，其包括将其中胺基与不对称碳原子键合的化合物的立体异构体混合物与手性助剂和成盐辅助化合物混合的步骤，其中 手性助剂是O，O'-二癸基酒石酸衍生物，更具体地说是2,3-二苯甲酰基 - 酒石酸或O，O'-二对甲苯基酒石酸，成盐辅助化合物是扁桃酸或 樟脑磺酸，并且通过使用该方法可以获得具有高光学纯度水平的光学异构体。 因此，根据本发明的一个方面，当制备具有高光学纯度的旋光异构体时，该方法可用于制药或化妆领域。

公开(公告)号：EP3162793A4

公开(公告)日：2018-01-03

申请号：EP16752647

申请日：2016-02-15

申请人： AMOREPACIFIC CORP

发明人： WOO BYOUNG YOUNG ,  LEE KI-WHA ,  SHIN KWANG-HYUN ,  PARK MIYOUNG ,  JUNG KYOUNGMI ,  CHOI JOONHO ,  CHOI GYEYOUNG ,  CHO WONKYUNG ,  PARK YOUNG-HO

IPC分类号： C07C303/36 ,  C07C303/42 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

CPC分类号： C07C303/42 ,  C07B57/00 ,  C07B2200/07 ,  C07C63/06 ,  C07C303/36 ,  C07C303/44 ,  C07C311/08 ,  C07D213/56

摘要： The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O' -diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O' -di- p -toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.