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公开(公告)号：EP0789563A1
公开(公告)日：1997-08-20
申请号：EP95938824.0
申请日：1995-10-05
发明人： PACHUK, Catherine J. , WANDS, Jack , WAKITA, Takaji , ZURAWSKI, Vincent R., Jr. , CONEY, Leslie R. , TOKUSHIGE, Katsutoshi
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2730/10122 , C12N2770/24222
摘要： Nucleic acid molecule that comprises an incomplete fused hepatitis C and hepatitis B viral genome or an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein or an incomplet hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein, operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
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公开(公告)号：EP0789563B1
公开(公告)日：2004-06-16
申请号：EP95938824.0
申请日：1995-10-05
发明人： PACHUK, Catherine J. , WANDS, Jack , WAKITA, Takaji , ZURAWSKI, Vincent R., Jr. , CONEY, Leslie R. , TOKUSHIGE, Katsutoshi
IPC分类号： A61K31/00 , A61K35/00 , A61K39/145 , C12N7/00 , C12N7/01 , C07K14/02 , C07K14/18 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2730/10122 , C12N2770/24222
摘要： Nucleic acid molecule that comprises an incomplete fused hepatitis C and hepatitis B viral genome or an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein or an incomplet hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein, operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
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公开(公告)号：EP0789563B8
公开(公告)日：2004-11-17
申请号：EP95938824.0
申请日：1995-10-05
申请人： APOLLON, INC. , The General Hospital Corporation doing business as The Massachusetts General Hospital
发明人： PACHUK, Catherine J. , WANDS, Jack , WAKITA, Takaji , ZURAWSKI, Vincent R., Jr. , CONEY, Leslie R. , TOKUSHIGE, Katsutoshi
IPC分类号： A61K31/00 , A61K35/00 , A61K39/145 , C12N7/00 , C12N7/01 , C07K14/02 , C07K14/18 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2730/10122 , C12N2770/24222
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