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714 条记录 (耗时 0.044 秒)

    COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION
    7.
    发明公开
    COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION 有权
    与二硫键连接的阳离子成分用于转染和免疫刺激络合核酸

    公开(公告)号：EP2449113A1

    公开(公告)日：2012-05-09

    申请号：EP11738625.0

    申请日：2011-07-25

    申请人： Curevac GmbH

    发明人： BAUMHOF, Patrick ,  VOSS, Söhnke ,  KRAMPS, Thomas ,  KALLEN, Karl-Josef

    IPC分类号： C12N15/87 ,  A61K48/00 ,  A61K47/34 ,  A61K47/48

    CPC分类号： A61K48/0041 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K47/645 ,  A61K2039/51 ,  A61K2039/55516 ,  A61K2039/55561 ,  C12N15/87 ,  Y02A50/412 ,  Y02A50/472

    摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.

    Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis
    8.
    发明公开
    Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis 失效
    Leishmanien-Antigene zur Verwendung bei der Therapie und Diagnus von Leishmaniose

    公开(公告)号：EP2284186A1

    公开(公告)日：2011-02-16

    申请号：EP10177490.9

    申请日：1998-02-12

    申请人： CORIXA CORPORATION

    发明人： Campos-Neto, Antonio ,  Webb, John ,  Dillon, Davin ,  Reed, Steven G ,  Skeiky, Yasir A W

    IPC分类号： C07K14/44 ,  C12N15/30 ,  A61K39/008 ,  G01N33/569

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/41

    摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

    摘要翻译： 公开了预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供了包含这种多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。

    Compounds and methods for treatment and diagnosis of chlamydial infection
    9.
    发明公开
    Compounds and methods for treatment and diagnosis of chlamydial infection 审中-公开
    Verbindungen und Verfahren zur Behandlung und Diagnosis von Chlamydia-Infektionen

    公开(公告)号：EP2223935A2

    公开(公告)日：2010-09-01

    申请号：EP10163839.3

    申请日：1999-12-08

    申请人： Corixa Corporation

    发明人： Probst, Peter ,  Bhatia, Ajay ,  Skeiky, Yasir A. W. ,  Fling, Steven P. ,  Jen, Shyian ,  Stromberg, Erica Jean

    IPC分类号： C07K14/295 ,  C07K19/00 ,  C12N15/62 ,  A61K39/118

    CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

    摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

    摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

    Compounds and methods for treatment and diagnosis of chlamydial infection
    10.
    发明公开
    Compounds and methods for treatment and diagnosis of chlamydial infection 审中-公开
    用于治疗和诊断衣原体感染的化合物和方法

    公开(公告)号：EP2218733A1

    公开(公告)日：2010-08-18

    申请号：EP10163838.5

    申请日：1999-12-08

    申请人： Corixa Corporation

    发明人： Probst, Peter ,  Bhatia, Ajay ,  Skeiky, Yasir A. W. ,  Fling, Steven ,  Jen, Shyian ,  Stromberg, Erica Jean

    IPC分类号： C07K14/295 ,  C07K19/00 ,  C12N15/62 ,  A61K39/118

    CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

    摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

    摘要翻译： 披露了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。