公开(公告)号：EP2798059A2

公开(公告)日：2014-11-05

申请号：EP12860313.1

申请日：2012-12-21

申请人： APSE LLC

发明人： ARHANCET, Juan Pedro Humberto ,  ARHANCET, Juan P. ,  DELANEY, Kimberly ,  HALL, Kathleen B. ,  SUMMERS, Neena

IPC分类号： C12N7/00 ,  C07H21/00

CPC分类号： C12N7/00 ,  A01N25/26 ,  A01N25/28 ,  C07K14/005 ,  C07K14/01 ,  C12N7/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/123 ,  C12N2310/128 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2330/51 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18142 ,  A01N43/70 ,  A01N47/40 ,  A01N57/12 ,  A01N57/14 ,  A01N57/30 ,  C12N2310/531

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.