公开(公告)号：EP2798059A2

公开(公告)日：2014-11-05

申请号：EP12860313.1

申请日：2012-12-21

申请人： APSE LLC

发明人： ARHANCET, Juan Pedro Humberto ,  ARHANCET, Juan P. ,  DELANEY, Kimberly ,  HALL, Kathleen B. ,  SUMMERS, Neena

IPC分类号： C12N7/00 ,  C07H21/00

CPC分类号： C12N7/00 ,  A01N25/26 ,  A01N25/28 ,  C07K14/005 ,  C07K14/01 ,  C12N7/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/123 ,  C12N2310/128 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2330/51 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18142 ,  A01N43/70 ,  A01N47/40 ,  A01N57/12 ,  A01N57/14 ,  A01N57/30 ,  C12N2310/531

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.

公开(公告)号：EP4019636A1

公开(公告)日：2022-06-29

申请号：EP21197081.9

申请日：2012-12-21

申请人： APSE LLC

发明人： ARHANCET, Juan, Pedro, Humberto ,  ARHANCET, Juan, P. ,  DELANEY, Kimberly ,  HALL, Kathleen, B. ,  SUMMERS, Neena

IPC分类号： C12N15/113 ,  C07K14/005 ,  C12N7/04

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.

公开(公告)号：EP3010494B1

公开(公告)日：2018-08-15

申请号：EP14813301.0

申请日：2014-06-05

申请人： APSE LLC

发明人： ARHANCET, Juan Pedro, Humberto ,  ARHANCET, Juan, P. ,  DELANEY, Kimberly ,  HALL, Kathleen, B. ,  SUMMERS, Neena ,  OATES, Edward

IPC分类号： A61K9/50 ,  C12N7/00 ,  C12N15/11

CPC分类号： C12N15/113 ,  A61K9/5184 ,  A61K48/00 ,  C07K14/005 ,  C12N15/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00023 ,  C12N2795/00042 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18142

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.

公开(公告)号：EP3010494A1

公开(公告)日：2016-04-27

申请号：EP14813301.0

申请日：2014-06-05

申请人： APSE LLC

发明人： ARHANCET, Juan Pedro, Humberto ,  ARHANCET, Juan, P. ,  DELANEY, Kimberly ,  HALL, Kathleen, B. ,  SUMMERS, Neena ,  OATES, Edward

IPC分类号： A61K9/50

CPC分类号： C12N15/113 ,  A61K9/5184 ,  A61K48/00 ,  C07K14/005 ,  C12N15/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00023 ,  C12N2795/00042 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18142

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.