公开(公告)号：EP3010494A4

公开(公告)日：2017-06-07

申请号：EP14813301

申请日：2014-06-05

申请人： APSE LLC

发明人： ARHANCET JUAN PEDRO HUMBERTO ,  ARHANCET JUAN P ,  DELANEY KIMBERLY ,  HALL KATHLEEN B ,  SUMMERS NEENA ,  OATES EDWARD

IPC分类号： A61K9/50

CPC分类号： C12N15/113 ,  A61K9/5184 ,  A61K48/00 ,  C12N15/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00023 ,  C12N2795/00042

摘要： Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.

摘要翻译： 描述了使用抗水解酶的病毒衣壳蛋白以制备病毒样颗粒以包封并随后分离和纯化目标货物分子（包括核酸如siRNA和shRNA，miRNA，信使RNA，小分子肽和生物活性物质）的新型方法和组合物 分子。