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公开(公告)号：EP1408978A2
公开(公告)日：2004-04-21
申请号：EP02742236.9
申请日：2002-06-21
发明人： METCALF, Chester, A., III , SHAKESPEARE, William, C. , SAWYER, Tomi, K. , WANG, Yihan , BOHACEK, Regine
IPC分类号： A61K31/505 , C07D409/14
CPC分类号： C07D239/42 , C07D401/04 , C07D403/04 , C07F9/65122 , C07F9/65127 , C07F9/65583
摘要： This invention relates to compounds of the general formula (I), in which R?A, RB, RC, RD¿, and z are as defined herein, and to their preparation and use.
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公开(公告)号：EP1408971A1
公开(公告)日：2004-04-21
申请号：EP02739935.1
申请日：2002-06-21
发明人： METCALF, Chester, A., III , SHAKESPEARE, William, C. , SAWYER, Tomi, K. , WANG, Yihan , BOHACEK, Regine
IPC分类号： A61K31/47 , C07D215/38 , C07D215/44
CPC分类号： C07F9/65583 , A61K31/47 , A61K45/06 , C07F9/4012 , C07F9/587 , C07F9/60 , A61K2300/00
摘要： This invention relates to compounds of the general formula: (I) in which R?A, RB, RC and RD¿ are as defined herein, and to their preparation and use.
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公开(公告)号：EP1244679B1
公开(公告)日：2006-11-15
申请号：EP00988184.8
申请日：2000-12-18
发明人： WEIGELE, Manfred , SAWYER, Tomi, K. , BOHACEK, Regine , SHAKESPEARE, William, C. , SUNDARAMOORTHI, Rajeswari , WANG, Yihan , DALGARNO, David, C. , METCALF, III, Chester, A.
IPC分类号： C07F9/6512
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/582 , C07F9/65583 , C07F9/6561 , C07F9/65616
摘要： This invention relates to compounds of general formula (I) in which R?A, RB, RC and RD¿ are as defined herein, and to their preparation and use.
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公开(公告)号：EP1246829A1
公开(公告)日：2002-10-09
申请号：EP00988160.8
申请日：2000-12-18
发明人： WEIGELE, Manfred , DALGARNO, David, C. , LUKE, George, P. , SAWYER, Tomi, K. , BOHACEK, Regine , SHAKESPEARE, William, C. , SUNDARAMOORTHI, Rajeswari , WANG, Yihan , METCALF, Chester, A., III , VU, Chi, B. , KAWAHATA, Noriyuki, H.
IPC分类号： C07F9/6512
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/6561 , C07F9/65616
摘要： The present invention relates to bone-targeting compounds useful for treating a variety of disorders and conditions, e.g., of bone tissue.
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公开(公告)号：EP1463742A2
公开(公告)日：2004-10-06
申请号：EP02742237.7
申请日：2002-06-21
发明人： SHAKESPEARE, William, C. , SAWYER, Tomi, K. , METCALF, Chester, A., III , WANG, Yihan , BOHACEK, Regine , SUNDARAMOORTHI, Rajeswari
IPC分类号： C07F9/6561 , A61K31/675 , A61P35/00 , A61P19/08 , A61P19/10
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/65616
摘要： The invention relates to compounds of the general formula: in which RA Rc and W are as defined herein, and to their preparation and use.
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6.发明公开BICYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITION CONTAINING THEM AND USES THEREOF 审中-公开信号转导的BIZYCLISCHE抑制剂;含氮组合物及其用途
公开(公告)号：EP1129068A1
公开(公告)日：2001-09-05
申请号：EP99962770.6
申请日：1999-11-12
发明人： SHAKESPEARE, William, C. , YANG, Michael, G. , SUNDARAMOORTHI, Rajeswari , BOHACEK, Regine , EYERMANN, Charles, Joseph , SAWYER, Tomi, K.
IPC分类号： C07C237/20 , C07C237/22 , C07C237/48 , C07F9/38 , C07F9/40 , C07D327/02 , C07D313/08 , A61K31/165 , A61P9/00 , A61P19/10 , A61P37/00
CPC分类号： C07F9/65527 , C07C237/48 , C07C2601/14 , C07C2602/12 , C07D313/08 , C07F9/12 , C07F9/3834 , C07F9/3873 , C07F9/3882 , C07F9/4021
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula (I) as defined herein.
摘要翻译： 本发明涉及的化合物用于抑制细胞内的信号转导，爱由一个或多个分子间的相互作用涉及含磷酸酪氨酸蛋白介导的细胞内特别的信号转导。 本发明因此涉及包含涉及所述化合物的医药和兽医给药的化合物和预防和治疗方法的药物组合物。 的化合物在限定的formulaas的。
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7.发明公开NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM 审中-公开使用抑制信号传输，SIE ENTHALTENDE ZUSAMMENSETZUNGEN
公开(公告)号：EP1030853A1
公开(公告)日：2000-08-30
申请号：EP98958550.0
申请日：1998-11-12
发明人： WEIGELE, Manfred , BOHACEK, Regine , JACOBSEN, Virginia, A. , MACEK, Karina , YANG, Michael, G. , KAWAHATA, Noriyuki, H. , SUNDARAMOORTHI, Rajeswari , WANG, Yihan , TAKEUCHI, Craig, S. , LUKE, George, P. , METCALF, Chester, A., III , SHAKESPEARE, William, C. , SAWYER, Tomi
IPC分类号： C07F9/38 , A61K31/66 , C07F9/12 , C07K5/06 , A61K38/05 , C07D307/89 , A61K31/35 , C07C237/22 , A61K31/165 , C07F9/655
CPC分类号： C07D307/92 , A61K38/00 , C07C237/22 , C07C2601/14 , C07F9/12 , C07F9/3834 , C07F9/3869 , C07F9/3873 , C07F9/3882 , C07F9/65527 , C07K5/06191
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (I) as defined herein.
摘要翻译： 本发明涉及用于抑制细胞内信号转导的化合物，特别是通过涉及含磷酸酪氨酸的蛋白质的一种或多种分子相互作用介导的细胞内信号转导。 本发明还涉及包含化合物的药物组合物和涉及化合物的药物和兽药施用的预防和治疗方法。 化合物是如本文所定义的式（1）。
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公开(公告)号：EP1259520B1
公开(公告)日：2006-05-24
申请号：EP00986551.0
申请日：2000-12-18
发明人： WEIGELE, Manfred , SHAKESPEARE, William , SAWYER, Tomi, K. , SUNDARAMOORTHI, Rajeswari , BOHACEK, Regine , WANG, Yihan , METCALF, Chester, A., III , DALGARNO, David, C.
IPC分类号： C07F9/6561
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/6561 , C07F9/65616
摘要： Novel phosphorous moieties containing purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.
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公开(公告)号：EP1412367A1
公开(公告)日：2004-04-28
申请号：EP02756260.2
申请日：2002-06-21
发明人： WANG, Yihan , METCALF, Chester, A., III , SHAKESPEARE, William, C. , SAWYER, Tomi, K. , BOHACEK, Regine
IPC分类号： C07F9/60
CPC分类号： C07F9/3821 , C07F9/4012 , C07F9/60 , C07F9/65583
摘要： The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives therof): in which R?A, RB, RC, R5, R7, R9, R9a¿, AK, p, q, r and X are defined herein, and to their preparation and use.
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公开(公告)号：EP1408985A1
公开(公告)日：2004-04-21
申请号：EP02739940.1
申请日：2002-06-21
发明人： METCALF, Chester, A., III , SHAKESPEARE, William, C. , SAWYER, Tomi, K. , WANG, Yihan , BOHACEK, Regine
IPC分类号： A61K31/675 , A61P19/08 , A61P19/10
CPC分类号： C07D471/04 , C07F9/4012 , C07F9/587 , C07F9/65066 , C07F9/650958 , C07F9/65583 , C07F9/6561
摘要： This invention relates to compounds of the general formula (I) in which R?A, RB and RC¿ are as defined herein, and to their preparation and use.
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