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公开(公告)号：EP3778584A1
公开(公告)日：2021-02-17
申请号：EP20178478.2
申请日：2015-05-13
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.
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公开(公告)号：EP3157916A1
公开(公告)日：2017-04-26
申请号：EP15810340.8
申请日：2015-05-13
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D403/14 , C07D473/16
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07F9/65583
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
摘要翻译： 本文描述了调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及化合物，药物组合物和治疗与激酶活性相关的疾病和病症的方法，包括突变型EGFR和突变型HER2活性。
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公开(公告)号：EP2704572B1
公开(公告)日：2015-12-30
申请号：EP12779411.3
申请日：2012-05-04
发明人： DALGARNO, David, C. , HUANG, Wei-sheng , SHAKESPEARE, William, C. , WANG, Yihan , ZHU, Xiaotian
IPC分类号： A01N43/54 , A01N43/66 , A61K31/505 , A61K31/53 , C07D401/00
CPC分类号： C07D239/48 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/505 , A61K31/506 , A61K31/538 , A61K31/553 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula I: wherein the variables are as defined herein.
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公开(公告)号：EP1973545B1
公开(公告)日：2013-01-30
申请号：EP06845939.5
申请日：2006-12-22
发明人： ZOU, Dong , HUANG, Wei-sheng , THOMAS, R., Mathew , ROMERO, Jan Antoinette, C. , QI, Jiwei , WANG, Yihan , ZHU, Xiaotian , SHAKESPEARE, William, C. , SUNDARAMOORTHI, Rajeswari , METCALF, Chester, A., III , DALGARNO, David, C. , SAWYER, Tomi, K.
IPC分类号： A61P35/00 , A61K31/4745 , A61K31/519 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5025 , C07D471/02 , C07D487/04 , C07D471/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
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公开(公告)号：EP2493460A1
公开(公告)日：2012-09-05
申请号：EP10827625.4
申请日：2010-11-01
发明人： HUANG, Wei-sheng , RIVERA, Victor, M. , CLACKSON, Timothy, P. , SHAKESPEARE, William, C. , SQUILLACE, Rachel, M. , GOZGIT, Joseph, M.
IPC分类号： A61K31/00 , A61K31/55 , A61K31/535
CPC分类号： C07D487/04 , A61K31/5025
摘要： The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-y1)-methyl)-3-(trifluoromethyl)phenyl)benzamide.
摘要翻译： （咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N-（4 - （（4-甲基哌嗪-1-基） ） - 甲基）-3-（三氟甲基）苯基）苯甲酰胺。
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公开(公告)号：EP2023933A2
公开(公告)日：2009-02-18
申请号：EP07756231.2
申请日：2007-05-08
发明人： WANG, Yihan , ZHU, Xiaotian , SUNDARAMOORTHI, Rajeswari , HUANG, Wei-sheng , ZOU, Dong , THOMAS, R., Mathew , QL, Jiwei , ROMERO, Jan Antionette, C. , DALGARNO, David, C. , SHAKESPEARE, William, C. , SAWYER, Tomi, K. , METCALF, Chester, A.
IPC分类号： A61K31/53 , A61K31/519 , A61K31/496 , A61K31/503 , A61K31/498
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula (I):in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：EP1973545A2
公开(公告)日：2008-10-01
申请号：EP06845939.5
申请日：2006-12-22
发明人： ZOU, Dong , HUANG, Wei-sheng , THOMAS, R., Mathew , ROMERO, Jan Antoinette, C. , QI, Jiwei , WANG, Yihan , ZHU, Xiaotian , SHAKESPEARE, William, C. , SUNDARAMOORTHI, Rajeswari , METCALF, Chester, A., III , DALGARNO, David, C. , SAWYER, Tomi, K.
IPC分类号： A61K31/4745 , A61K31/519 , C07D471/02
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：EP3417912B1
公开(公告)日：2020-08-12
申请号：EP18183366.6
申请日：2006-12-22
发明人： ZOU, Dong , METCALF, Chester A, III , DALGARNO, David C , SAWYER, Tomi K , HUANG, Wei-sheng , THOMAS, Mathew R , ROMERO, Jan Antoinette C , QI, Jiwei , WANG, Yihan , ZHU, Xiaotian , SHAKESPEARE, William C , SUNDARAMOORTHI, Rajeswari
IPC分类号： A61P35/00 , A61K31/4745 , A61K31/519 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5025 , C07D471/02 , C07D487/04 , C07D471/04 , C07D473/34
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公开(公告)号：EP3409669A1
公开(公告)日：2018-12-05
申请号：EP18182201.6
申请日：2015-05-13
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D405/12 , C07D471/04 , C07D401/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
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公开(公告)号：EP3409669B1
公开(公告)日：2020-10-07
申请号：EP18182201.6
申请日：2015-05-13
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D405/12 , C07D471/04 , C07D401/04
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